Noise in biology
LS Tsimring - Reports on Progress in Physics, 2014 - iopscience.iop.org
Noise permeates biology on all levels, from the most basic molecular, sub-cellular
processes to the dynamics of tissues, organs, organisms and populations. The functional …
processes to the dynamics of tissues, organs, organisms and populations. The functional …
Bistability, epigenetics, and bet-hedging in bacteria
Clonal populations of microbial cells often show a high degree of phenotypic variability
under homogeneous conditions. Stochastic fluctuations in the cellular components that …
under homogeneous conditions. Stochastic fluctuations in the cellular components that …
A stochastic single-molecule event triggers phenotype switching of a bacterial cell
By monitoring fluorescently labeled lactose permease with single-molecule sensitivity, we
investigated the molecular mechanism of how an Escherichia coli cell with the lac operon …
investigated the molecular mechanism of how an Escherichia coli cell with the lac operon …
Markovian dynamics on complex reaction networks
J Goutsias, G Jenkinson - Physics reports, 2013 - Elsevier
Complex networks, comprised of individual elements that interact with each other through
reaction channels, are ubiquitous across many scientific and engineering disciplines …
reaction channels, are ubiquitous across many scientific and engineering disciplines …
Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism
Early T-cell activation is selected by evolution to discriminate a few foreign peptides rapidly
from a vast excess of self-peptides, and it is unclear in quantitative terms how this is …
from a vast excess of self-peptides, and it is unclear in quantitative terms how this is …
Noise-induced mechanism for biological homochirality of early life self-replicators
The observed single-handedness of biological amino acids and sugars has long been
attributed to autocatalysis. However, the stability of homochiral states in deterministic …
attributed to autocatalysis. However, the stability of homochiral states in deterministic …
Nonequilibrium thermodynamics in cell biology: Extending equilibrium formalism to cover living systems
X Fang, J Wang - Annual review of biophysics, 2020 - annualreviews.org
We discuss new developments in the nonequilibrium dynamics and thermodynamics of
living systems, giving a few examples to demonstrate the importance of nonequilibrium …
living systems, giving a few examples to demonstrate the importance of nonequilibrium …
A comparison of deterministic and stochastic modeling approaches for biochemical reaction systems: On fixed points, means, and modes
SK Hahl, A Kremling - Frontiers in genetics, 2016 - frontiersin.org
In the mathematical modeling of biochemical reactions, a convenient standard approach is
to use ordinary differential equations (ODEs) that follow the law of mass action. However …
to use ordinary differential equations (ODEs) that follow the law of mass action. However …
Cooperativity in cellular biochemical processes: noise-enhanced sensitivity, fluctuating enzyme, bistability with nonlinear feedback, and other mechanisms for …
H Qian - Annual review of biophysics, 2012 - annualreviews.org
Cooperativity in classical biophysics originates from molecular interactions; nonlinear
feedbacks in biochemical networks regulate dynamics inside cells. Using stochastic reaction …
feedbacks in biochemical networks regulate dynamics inside cells. Using stochastic reaction …
Stochastic phenotype transition of a single cell in an intermediate region of gene state switching
Multiple phenotypic states often arise in a single cell with different gene-expression states
that undergo transcription regulation with positive feedback. Recent experiments show that …
that undergo transcription regulation with positive feedback. Recent experiments show that …