Senolytics are a category of drugs that reduce the impact of cellular senescence, an effect
associated with a range of chronic and age‐related diseases. Since the discovery of the first …

The development of most solid cancers, including pancreatic, breast, lung, liver, and ovarian
cancer, involves a desmoplastic reaction: a process of major remodeling of the extracellular …

Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …

Significance Cellular growth arrest, associated with 'senescence', helps to safeguard against
the accumulation of DNA damage which is often recognized as the underlying mechanism of …

The benefits of high-fever range hyperthermia have been utilized in medicine from the
Ancient Greek culture to the present day. Amplitude-modulated electro-hyperthermia …

The tumor physical microenvironment (TPME) contributes to cancer chemoresistance in both
mechanical and mechanobiological approaches. Along with chemotherapy, the tumor …

Cell senescence is critical in diverse aspects of organism life. It is involved in tissue
development and homeostasis, as well as in tumor suppression. Consequently, it is tightly …

Over the past decade, the emergence of patient-derived tumor organoids (PDTOs) has
broadened the repertoire of preclinical models and progressively revolutionized three …

Polyploidy is a conserved mechanism in cell development and stress responses. Multiple
stresses of treatment, including radiation and chemotherapy drugs, can induce the …

The well-recognized cell phenotypic heterogeneity in tumors is a great challenge for cancer
treatment. Dynamic interconversion and movement within a spectrum of different cell …