The last 15 years have seen an explosion of new findings on the role of complement, a
major arm of the immune system, in the central nervous system (CNS) compartment …

Multiple sclerosis (MS) is a chronic disease that is characterized by the inappropriate
invasion of lymphocytes and monocytes into the central nervous system (CNS), where they …

The integrity of the genome is under constant threat of environmental and endogenous
agents that cause DNA damage. Endogenous damage is particularly pervasive, occurring at …

IFN-β remains the most widely prescribed treatment for relapsing remitting multiple sclerosis.
Despite widespread use of IFN-β, the therapeutic mechanism is still partially understood …

The presence of B lymphocyte–associated oligoclonal immunoglobulins in the
cerebrospinal fluid is a classic hallmark of multiple sclerosis (MS). The clinical efficacy of anti …

Central neurological disorders are significant contributors to morbidity, mortality, and long-
term disability globally in modern society. These encompass neurodegenerative diseases …

Subpial demyelination is a specific hallmark of multiple sclerosis and a correlate of disease
progression. Although the mechanism (s) that mediate pathogenesis in the subpial …

The success of B cell depletion therapies and identification of leptomeningeal ectopic
lymphoid tissue (ELT) in patients with multiple sclerosis (MS) has renewed interest in the …

Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system
(CNS) affecting nearly three million humans worldwide. In MS, cells of an auto-reactive …

B cell–depleting therapies have been shown to ameliorate symptoms in multiple sclerosis
(MS) patients; however, the mechanism of action remains unclear. Following priming with …