Antifungal agents: spectrum of activity, pharmacology, and clinical indications
Continued advancement of medical science offers life-saving treatment options for a variety
of hematologic, oncologic, and rheumatologic conditions. Immunosuppression, a common …
of hematologic, oncologic, and rheumatologic conditions. Immunosuppression, a common …
Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents
C Spampinato, D Leonardi - BioMed research international, 2013 - Wiley Online Library
The genus Candida includes about 200 different species, but only a few species are human
opportunistic pathogens and cause infections when the host becomes debilitated or …
opportunistic pathogens and cause infections when the host becomes debilitated or …
Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America
TF Patterson, GR Thompson III… - Clinical infectious …, 2016 - academic.oup.com
It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …
patients. They are not intended to supplant physician judgment with respect to particular …
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP2C19 and Voriconazole Therapy
B Moriyama, AO Obeng, J Barbarino… - Clinical …, 2017 - Wiley Online Library
Voriconazole, a triazole antifungal agent, demonstrates wide interpatient variability in serum
concentrations, due in part to variant CYP2C19 alleles. Individuals who are CYP2C19 …
concentrations, due in part to variant CYP2C19 alleles. Individuals who are CYP2C19 …
Tissue penetration of antifungal agents
Understanding the tissue penetration of systemically administered antifungal agents is
critical for a proper appreciation of their antifungal efficacy in animals and humans. Both the …
critical for a proper appreciation of their antifungal efficacy in animals and humans. Both the …
Defining breakthrough invasive fungal infection–Position paper of the mycoses study group education and research consortium and the European Confederation of …
Breakthrough invasive fungal infections (IFI s) have emerged as a significant problem in
patients receiving systemic antifungals; however, consensus criteria for defining …
patients receiving systemic antifungals; however, consensus criteria for defining …
Polymorphism of human cytochrome P450 enzymes and its clinical impact
Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …
specific genes affect drug response. This article highlights current pharmacogenetic …
Current concepts in antifungal pharmacology
RE Lewis - Mayo Clinic Proceedings, 2011 - Elsevier
The introduction of new antifungal agents (eg, echinocandins, second-generation triazoles)
in the past decade has transformed the management of invasive mycoses to the point that …
in the past decade has transformed the management of invasive mycoses to the point that …
The effect of therapeutic drug monitoring on safety and efficacy of voriconazole in invasive fungal infections: a randomized controlled trial
Background. Blood levels of voriconazole, a first line therapy for invasive aspergillosis, may
correlate with adverse events and treatment response. However, no randomized controlled …
correlate with adverse events and treatment response. However, no randomized controlled …
Clinical relevance of the pharmacokinetic interactions of azole antifungal drugs with other coadministered agents
RJM Brüggemann, JWC Alffenaar… - Clinical Infectious …, 2009 - academic.oup.com
There are currently a number of licensed azole antifungal drugs; however; only 4 (namely,
fluconazole, itraconazole, posaconazole, and voriconazole) are used frequently in a clinical …
fluconazole, itraconazole, posaconazole, and voriconazole) are used frequently in a clinical …