Hydrogel microparticles for biomedical applications

AC Daly, L Riley, T Segura, JA Burdick - Nature Reviews Materials, 2020 - nature.com
Hydrogel microparticles (HMPs) are promising for biomedical applications, ranging from the
therapeutic delivery of cells and drugs to the production of scaffolds for tissue repair and …

Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Influence of microgel fabrication technique on granular hydrogel properties

VG Muir, TH Qazi, J Shan, J Groll… - … Biomaterials Science & …, 2021 - ACS Publications
Bulk hydrogels traditionally used for tissue engineering and drug delivery have numerous
limitations, such as restricted injectability and a nanoscale porosity that reduces cell …

Sticking together: injectable granular hydrogels with increased functionality via dynamic covalent inter‐particle crosslinking

VG Muir, TH Qazi, S Weintraub, BO Torres Maldonado… - Small, 2022 - Wiley Online Library
Granular hydrogels are an exciting class of microporous and injectable biomaterials that are
being explored for many biomedical applications, including regenerative medicine, 3D …

Designing microgels for cell culture and controlled assembly of tissue microenvironments

AS Caldwell, BA Aguado… - Advanced functional …, 2020 - Wiley Online Library
Micrometer‐sized hydrogels, termed microgels, are emerging as multifunctional platforms
that can recapitulate tissue heterogeneity in engineered cell microenvironments. The …

Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer

NF Truong, E Kurt, N Tahmizyan, SC Lesher-Pérez… - Acta biomaterialia, 2019 - Elsevier
Designing scaffolds for polyplex-mediated therapeutic gene delivery has a number of
applications in regenerative medicine, such as for tissue repair after wounding or disease …

Mechanical reinforcement of granular hydrogels

A Charlet, F Bono, E Amstad - Chemical science, 2022 - pubs.rsc.org
Granular hydrogels are composed of hydrogel-based microparticles, so-called microgels,
that are densely packed to form an ink that can be 3D printed, injected or cast into …

Translating therapeutic microgels into clinical applications

Y Kittel, AJC Kuehne… - Advanced Healthcare …, 2022 - Wiley Online Library
Microgels are crosslinked, water‐swollen networks with a 10 nm to 100 µm diameter and
can be modified chemically or biologically to render them biocompatible for advanced …

Click by click microporous annealed particle (MAP) scaffolds

NJ Darling, W Xi, E Sideris… - Advanced …, 2020 - Wiley Online Library
Macroporous scaffolds are being increasingly used in regenerative medicine and tissue
repair. While the recently developed microporous annealed particle (MAP) scaffolds have …

Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke

E Sideris, S Kioulaphides, KL Wilson, A Yu… - Advanced …, 2022 - Wiley Online Library
Increasing numbers of individuals live with stroke related disabilities. Following stroke,
highly reactive astrocytes and pro‐inflammatory microglia can release cytokines and lead to …