Abstract RAS (KRAS, NRAS and HRAS) is the most frequently mutated gene family in
cancers, and, consequently, investigators have sought an effective RAS inhibitor for more …

Ras is frequently mutated in cancer, however, there is a lack of consensus in the literature
regarding the cancer mutation frequency of Ras, with quoted values varying from 10%–30 …

The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter-and intra-
cellular communication, which regulates fundamental cell functions such as growth, survival …

RAS proteins are binary switches, cycling between ON and OFF states during signal
transduction. These switches are normally tightly controlled, but in RAS-related diseases …

The mechanism by which the wild-type KRAS allele imparts a growth inhibitory effect to
oncogenic KRAS in various cancers, including lung adenocarcinoma (LUAD), is poorly …

Over the last several decades, an impressive array of advanced microscopic and analytical
tools, such as single-particle tracking and nanoscopic fluorescence correlation …

K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that
comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative …

RAS has long been viewed as undruggable due to its lack of deep pockets for binding of
small molecule inhibitors. However, recent successes in the development of direct RAS …

During the last 100 years, cell signaling has evolved into a common mechanism for most
physiological processes across systems. Although the majority of cell signaling principles …

To execute their many vital functions, cell membranes are highly organized. Here, we review
how membrane structure shapes signal transduction across membranes. Recent …