Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Cardiovascular disease is one of the main causes of human mortality. Cytokines play crucial
roles in the development of cardiovascular disease. Interleukin (IL)-6 family members are a …

Cardiovascular disease is the leading cause of death worldwide. Advanced insights into
disease mechanisms and therapeutic strategies require a deeper understanding of the …

Tissue fibrosis and organ dysfunction are hallmarks of age-related diseases including heart
failure, but it remains elusive whether there is a common pathway to induce both events …

Background: A key cause of the high mortality of cardiovascular diseases is the
cardiomyocyte inability to renew after cardiac injury. As a promising strategy to supplement …

Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with a complex
microenvironment. Dichotomous tumour-promoting and-restrictive roles have been ascribed …

Objective: This study aimed to explore the role of circular RNAs (circRNAs) in M2
macrophage (M2M)-derived small extracellular vesicles (SEVs) in myocardial fibrosis …

High altitude (hypobaric hypoxia) triggers several mechanisms to compensate for the
decrease in oxygen bioavailability. One of them is pulmonary artery vasoconstriction and its …

Fibrotic remodeling of the heart in response to injury contributes to heart failure, yet
therapies to treat fibrosis remain elusive. Yes-associated protein (YAP) is activated in …

Conduction disorders and arrhythmias remain difficult to treat and are increasingly prevalent
owing to the increasing age and body mass of the general population, because both are risk …