The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue
in the periodontal region. Although dysbiosis of the local microbial community initiates local …

The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the
immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling …

IL-2 was first identified as a growth factor capable of driving the expansion of activated
human T cell populations. In the more than 40 years since its discovery, a tremendous …

Interleukin-2 (IL-2), the first cytokine that was molecularly cloned, was shown to be a T cell
growth factor essential for the proliferation of T cells and the generation of effector and …

The common cytokine receptor γ chain, γ c, is a component of the receptors for interleukin-2
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …

Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …

Clonal alterations in hematopoietic cells occur during aging and are often associated with
the establishment of a subclinical inflammatory environment. Several age-related conditions …

Despite advances in the treatment of psoriasis, there is an unmet need for effective and safe
oral treatments. The Janus Kinase–Signal Transducer and Activator of Transcription (JAK …

Immune homeostasis is heavily dependent on the action of regulatory T cells (Tregs) which
act to suppress the activation of many immune cell types including autoreactive conventional …