Faster, better, and cheaper: harnessing microfluidics and mass spectrometry for biotechnology

NS Ha, M de Raad, A Golini, CJ Petzold… - RSC chemical …, 2021 - pubs.rsc.org
High-throughput screening technologies are widely used for elucidating biological activities.
These typically require trade-offs in assay specificity and sensitivity to achieve higher …

Recent progress toward microfluidic quality control testing of radiopharmaceuticals

NS Ha, S Sadeghi, RM Van Dam - Micromachines, 2017 - mdpi.com
Radiopharmaceuticals labeled with short-lived positron-emitting or gamma-emitting isotopes
are injected into patients just prior to performing positron emission tomography (PET) or …

The current role of microfluidics in radiofluorination chemistry

KA Knapp, ML Nickels, HC Manning - Molecular Imaging and Biology, 2020 - Springer
The current utilization of positron emission tomography (PET) imaging is limited due to the
high costs associated with production facility start-up and operations; subsequently, there …

Microchip electrophoresis: A suitable analytical technique for pharmaceuticals quality control? A critical review

A Dispas, P Emonts, M Fillet - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Quality control (QC) is a major concern in the pharmaceutical industry to ensure medicines
quality and patient's safety. QC analysis are currently performed using several well-known …

Application of an electrokinetic backflow for enhancing pressure-driven charge based separations in sub-micrometer deep channels

L Xia, R Deb, N Yanagisawa, D Dutta - Analytica Chimica Acta, 2022 - Elsevier
In this article, we report significant improvements in the resolving power of pressure-driven
charge based separations performed in sub-micrometer deep glass channels upon …

Toward miniaturized analysis of chemical identity and purity of radiopharmaceuticals via microchip electrophoresis

J Ly, NS Ha, S Cheung, RM van Dam - Analytical and bioanalytical …, 2018 - Springer
Miniaturized synthesis of positron emission tomography (PET) tracers is poised to offer
numerous advantages including reduced tracer production costs and increased availability …

A novel planar grounded capacitively coupled contactless conductivity detector for microchip electrophoresis

J Wang, Y Liu, W He, Y Chen, H You - Micromachines, 2022 - mdpi.com
In the microchip electrophoresis with capacitively coupled contactless conductivity detection,
the stray capacitance of the detector causes high background noise, which seriously affects …

[HTML][HTML] Hydrodynamic injection for microchip electrophoresis: Development of an innovative passive system

A Dispas, P Emonts, D Vandormael, D Bernier… - Green Analytical …, 2024 - Elsevier
The world is facing challenges in terms of environmental sustainability and rising costs. In
this context, miniaturized equipment such as microfluidic devices can be used to manipulate …

Integration of high-resolution radiation detector for hybrid microchip electrophoresis

J Jones, NS Ha, AG Barajas… - Analytical …, 2020 - ACS Publications
For decades, there has been immense progress in miniaturizing analytical methods based
on electrophoresis to improve sensitivity and to reduce sample volumes, separation times …

Use of capillary electrophoresis for the determination of impurities in preparations of fluorine-18 labelled PET radiopharmaceuticals

D Antuganov, Y Antuganova, T Zykova… - … of Pharmaceutical and …, 2019 - Elsevier
Fluorine-18 labelled radiotracers are the most common diagnostic agents employed in
positron emission tomography (PET). Despite well-established quality control (QC) …