CREB and its close relatives are now widely accepted as prototypical stimulus-inducible
transcription factors. In many cell types, these factors function as effector molecules that …

Although the critical role for epigenetic mechanisms in development and cell differentiation
has long been appreciated, recent evidence reveals that these mechanisms are also …

Tumor innervation is a common phenomenon with unknown mechanism. Here, we
discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de …

PPARγ coactivator 1α (PGC-1α) is a potent stimulator of mitochondrial biogenesis and
respiration. Since the mitochondrial electron transport chain is the main producer of reactive …

J. Neurochem.(2011) 116, 1–9. Abstract Since its initial characterization over 20 years ago,
there has been intense and unwavering interest in understanding the role of the …

Sensory experience and the resulting synaptic activity within the brain are critical for the
proper development of neural circuits. Experience-driven synaptic activity causes membrane …

Calcium ions are ubiquitous and versatile signaling molecules, capable of decoding a
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …

Mutations in MeCP2, which encodes a protein that has been proposed to function as a
global transcriptional repressor, are the cause of Rett syndrome (RT T), an X-linked …

The effects of transcranial direct current stimulation (tDCS) on brain functions and the
underlying molecular mechanisms are yet largely unknown. Here we report that mice …

Coordinated activity-induced transcriptional changes across multiple neuron subtypes of the
prefrontal cortex (PFC) play a pivotal role in encoding and regulating major cognitive …