Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …

Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

Patient-specific ex vivo models of human tumours that recapitulate the pathological
characteristics and complex ecology of native tumours could help determine the most …

Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …

One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple
physiological processes. These include biosynthesis (purines and thymidine), amino acid …

Mitochondria are bioenergetic, biosynthetic, and signaling organelles that are integral in
stress sensing to allow for cellular adaptation to the environment. Therefore, it is not …

Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …

Tumors reprogram pathways of nutrient acquisition and metabolism to meet the
bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed …

Serine/glycine biosynthesis and one-carbon metabolism are crucial in sustaining cancer cell
survival and rapid proliferation, and of high clinical relevance. Excessive activation of …

The non-essential amino acid serine supports several metabolic processes that are crucial
for the growth and survival of proliferating cells, including protein, amino acid and …