[HTML][HTML] Metabolism of amino acids in cancer
Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …
[HTML][HTML] The role of ubiquitination and deubiquitination in cancer metabolism
T Sun, Z Liu, Q Yang - Molecular cancer, 2020 - Springer
Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy
Patient-specific ex vivo models of human tumours that recapitulate the pathological
characteristics and complex ecology of native tumours could help determine the most …
characteristics and complex ecology of native tumours could help determine the most …
[PDF][PDF] One-carbon metabolism in health and disease
GS Ducker, JD Rabinowitz - Cell metabolism, 2017 - cell.com
One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple
physiological processes. These include biosynthesis (purines and thymidine), amino acid …
physiological processes. These include biosynthesis (purines and thymidine), amino acid …
[HTML][HTML] Mitochondria and cancer
S Vyas, E Zaganjor, MC Haigis - Cell, 2016 - cell.com
Mitochondria are bioenergetic, biosynthetic, and signaling organelles that are integral in
stress sensing to allow for cellular adaptation to the environment. Therefore, it is not …
stress sensing to allow for cellular adaptation to the environment. Therefore, it is not …
Metabolomics: beyond biomarkers and towards mechanisms
Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …
Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
Fundamentals of cancer metabolism
RJ DeBerardinis, NS Chandel - Science advances, 2016 - science.org
Tumors reprogram pathways of nutrient acquisition and metabolism to meet the
bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed …
bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed …
Serine and one-carbon metabolism in cancer
M Yang, KH Vousden - Nature Reviews Cancer, 2016 - nature.com
The non-essential amino acid serine supports several metabolic processes that are crucial
for the growth and survival of proliferating cells, including protein, amino acid and …
for the growth and survival of proliferating cells, including protein, amino acid and …
Methionine is a metabolic dependency of tumor-initiating cells
Understanding cellular metabolism holds immense potential for developing new classes of
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …