Review and consensus on pharmacogenomic testing in psychiatry

CA Bousman, SA Bengesser, KJ Aitchison… - …, 2021 - thieme-connect.com
The implementation of pharmacogenomic (PGx) testing in psychiatry remains modest, in part
due to divergent perceptions of the quality and completeness of the evidence base and …

Barriers to clinical adoption of pharmacogenomic testing in psychiatry: a critical analysis

CR Virelli, AG Mohiuddin, JL Kennedy - Translational psychiatry, 2021 - nature.com
Pharmacogenomics (PGx) is the study of genetic influences on an individual's response to
medications. Improvements in the quality and quantity of PGx research over the past two …

[HTML][HTML] Impact of pharmacogenomics on clinical outcomes in major depressive disorder in the GUIDED trial: a large, patient-and rater-blinded, randomized, controlled …

JF Greden, SV Parikh, AJ Rothschild, ME Thase… - Journal of psychiatric …, 2019 - Elsevier
Current prescribing practices for major depressive disorder (MDD) produce limited treatment
success. Although pharmacogenomics may improve outcomes by identifying genetically …

Pharmacogenetic tests and depressive symptom remission: a meta-analysis of randomized controlled trials

CA Bousman, K Arandjelovic, SG Mancuso… - …, 2019 - Taylor & Francis
Aim: To conducted a systematic review and meta-analysis of prospective, randomized
controlled trials (RCTs) that examined pharmacogenetic-guided decision support tools …

Challenges and future prospects of precision medicine in psychiatry

M Manchia, C Pisanu, A Squassina… - Pharmacogenomics …, 2020 - Taylor & Francis
Precision medicine is increasingly recognized as a promising approach to improve disease
treatment, taking into consideration the individual clinical and biological characteristics …

Effect of pharmacogenomics testing guiding on clinical outcomes in major depressive disorder: a systematic review and meta-analysis of RCT

X Wang, C Wang, Y Zhang, Z An - BMC psychiatry, 2023 - Springer
Background Pharmacogenomic testing guided treatment have been developed to guide
drug selection or conversion in major depressive disorder patients. Whether patients benefit …

Economic evaluation in psychiatric pharmacogenomics: a systematic review

K Karamperis, M Koromina, P Papantoniou… - The …, 2021 - nature.com
Nowadays, many relevant drug–gene associations have been discovered, but
pharmacogenomics (PGx)-guided treatment needs to be cost-effective as well as clinically …

Genotype, phenotype, and medication recommendation agreement among commercial pharmacogenetic-based decision support tools

CA Bousman, BW Dunlop - The Pharmacogenomics Journal, 2018 - nature.com
The degree of agreement between four commercial pharmacogenetic-based decision
support tools (DSTs) was examined in five outpatients with major depressive disorder and at …

On the utilization of polygenic risk scores for therapeutic targeting

G Gibson - PLoS genetics, 2019 - journals.plos.org
The promise of personalized genomic medicine is that knowledge of a person's gene
sequences and activity will facilitate more appropriate medical interventions, particularly …

Real-world impact of a pharmacogenomics-enriched comprehensive medication management program

JP Jarvis, AP Peter, M Keogh, V Baldasare… - Journal of Personalized …, 2022 - mdpi.com
The availability of clinical decision support systems (CDSS) and other methods for
personalizing medicine now allows evaluation of their real-world impact on healthcare …