Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …

Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …

Background An ideal animal model to study SARS-coronavirus 2 (SARS-CoV-2)
pathogenesis and evaluate therapies and vaccines should reproduce SARS-CoV-2 infection …

Toll-like receptor 8 (TLR8) recognizes pathogen-derived single-stranded RNA fragments to
trigger innate and adaptive immune responses. Chronic hepatitis B (CHB) is associated with …

Hepatitis B virus infection affects over 250 million chronic carriers, causing more than
800,000 deaths annually, although a safe and effective vaccine is available. Currently used …

Toll-like receptors (TLRs) are members of a large family of evolutionarily conserved pattern
recognition receptors (PRRs), which serve as key components of the innate immune system …

Respiratory virus infections initiate in the upper respiratory tract (URT). Innate immunity is
critical for initial control of infection at this site, particularly in the absence of mucosal virus …

Activation of the toll-like receptors 7 and 8 has emerged as a promising strategy for cancer
immunotherapy. Herein, we report the design and synthesis of a series of pyrido [3, 2-d] …

Toll-like receptors 7 and 8 are involved in modulating the adaptive and innate immune
responses, and their activation has shown promise as a therapeutic strategy in the field of …

Several synthetic heterocyclic small molecules like imiquimod, resiquimod, CL097, CL075,
bromopirone, tilorone, loxoribine and isatoribine demonstrated TLR7/8 agonistic activity and …