Signaling pathways in obesity: mechanisms and therapeutic interventions
X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …
excessive fat accumulation in the body, obesity sharply increases the risk of several …
The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
Abstract Fibroblast growth factor 21 (FGF21) is a stress-inducible hormone that has
important roles in regulating energy balance and glucose and lipid homeostasis through a …
important roles in regulating energy balance and glucose and lipid homeostasis through a …
FGF21: an emerging therapeutic target for non-alcoholic steatohepatitis and related metabolic diseases
EJ Tillman, T Rolph - Frontiers in endocrinology, 2020 - frontiersin.org
The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …
FGF21 as modulator of metabolism in health and disease
C Tezze, V Romanello, M Sandri - Frontiers in physiology, 2019 - frontiersin.org
Fibroblast growth factor 21 (FGF21) is a hormone that regulates important metabolic
pathways. FGF21 is expressed in several metabolically active organs and interacts with …
pathways. FGF21 is expressed in several metabolically active organs and interacts with …
Therapeutic landscape for NAFLD in 2020
BA Neuschwander-Tetri - Gastroenterology, 2020 - Elsevier
Lifestyle modifications focused on healthy eating and regular exercise are the primary
recommendations for patients with nonalcoholic steatohepatitis (NASH). However, for …
recommendations for patients with nonalcoholic steatohepatitis (NASH). However, for …
Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase
Autophagy is essential for cellular survival and energy homeostasis under nutrient
deprivation. Despite the emerging importance of nuclear events in autophagy regulation …
deprivation. Despite the emerging importance of nuclear events in autophagy regulation …
DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C
The integrity of the nuclear envelope (NE) is essential for maintaining the structural stability
of the nucleus. Rupture of the NE has been frequently observed in cancer cells, especially in …
of the nucleus. Rupture of the NE has been frequently observed in cancer cells, especially in …
[HTML][HTML] Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction
Low-protein diets promote metabolic health in humans and rodents. Despite evidence that
sex and genetic background are key factors in the response to diet, most protein intake …
sex and genetic background are key factors in the response to diet, most protein intake …
Fibroblast growth factor–based pharmacotherapies for the treatment of obesity-related metabolic complications
The fibroblast growth factor (FGF) family, which comprises 22 structurally related proteins,
plays diverse roles in cell proliferation, differentiation, development, and metabolism. Among …
plays diverse roles in cell proliferation, differentiation, development, and metabolism. Among …
Protein, amino acids and obesity treatment
M Simonson, Y Boirie, C Guillet - Reviews in endocrine and metabolic …, 2020 - Springer
Dietary proteins have been used for years to treat obesity. Body weight loss is beneficial
when it concerns fat mass, but loss of fat free mass–especially muscle might be detrimental …
when it concerns fat mass, but loss of fat free mass–especially muscle might be detrimental …