Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

Mitochondrial permeability transition (MPT) is the sudden loss in the permeability of the
inner mitochondrial membrane (IMM) to low-molecular-weight solutes. Due to osmotic …

Background Muscle wasting and weakness in Duchenne muscular dystrophy (DMD) causes
severe locomotor limitations and early death due in part to respiratory muscle failure. Given …

In C. elegans, mutants that are defective in muscle function and/or structure are easy to
detect and analyze since: 1) body wall muscle is essential for locomotion, and 2) muscle …

Duchenne muscular dystrophy (DMD) is characterized by a pronounced and progressive
degradation of the structure of skeletal muscles, which decreases their strength and lowers …

Muscular dystrophies are a group of diseases characterised by the primary wasting of
skeletal muscle, which compromises patient mobility and in the most severe cases originate …

The redox-active protein cytochrome c is a highly positively charged hemoglobin that
regulates cell fate decisions of life and death. Under normal physiological conditions …

Mitochondria fragmentation destabilizes mitochondrial membranes, promotes oxidative
stress and facilitates cell death, thereby contributing to the development and the progression …

Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD), a common
muscle disease that manifests with muscle weakness, wasting, and degeneration. An …