Late-stage C–H functionalization offers new opportunities in drug discovery
L Guillemard, N Kaplaneris, L Ackermann… - Nature Reviews …, 2021 - nature.com
Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …
Organic synthesis with the most abundant transition metal–iron: from rust to multitasking catalysts
In industries and academic laboratories, several late transition metal-catalyzed prerequisite
reactions are widely performed during single and multistep synthesis. However, besides the …
reactions are widely performed during single and multistep synthesis. However, besides the …
3d transition metals for C–H activation
C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …
notable applications to material sciences, crop protection, drug discovery, and …
[HTML][HTML] A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry
C Sambiagio, D Schönbauer, R Blieck… - Chemical Society …, 2018 - pubs.rsc.org
The present review is devoted to summarizing the recent advances (2015–2017) in the field
of metal-catalysed group-directed C–H functionalisation. In order to clearly showcase the …
of metal-catalysed group-directed C–H functionalisation. In order to clearly showcase the …
Strategic evolution in transition metal-catalyzed directed C–H bond activation and future directions
In the field of C–H bond functionalization chemistry, directed C–H bond activation strategies
are highly appreciated due to the high efficiency and selectivity of such reactions towards a …
are highly appreciated due to the high efficiency and selectivity of such reactions towards a …
Transient directing groups for transformative C–H activation by synergistic metal catalysis
P Gandeepan, L Ackermann - Chem, 2018 - cell.com
The development of methods for the functionalization of otherwise inert C–H bonds is one of
the major foci in molecular syntheses. Recent advances have significantly improved the …
the major foci in molecular syntheses. Recent advances have significantly improved the …
Metal–organic cooperative catalysis in C–H and C–C bond activation
DS Kim, WJ Park, CH Jun - Chemical Reviews, 2017 - ACS Publications
Transition-metal-catalyzed activation of C–H and C–C bonds is a challenging area in
synthetic organic chemistry. Among various methods to accomplish these processes, the …
synthetic organic chemistry. Among various methods to accomplish these processes, the …
Accessing Remote meta‐ and para‐C(sp2)−H Bonds with Covalently Attached Directing Groups
Directing group assisted ortho‐C− H activation has been known for the last few decades. In
contrast, extending the same approach to achieve activation of the distal meta‐and para‐C …
contrast, extending the same approach to achieve activation of the distal meta‐and para‐C …
Construction of Quaternary Stereocenters by Palladium‐Catalyzed Carbopalladation‐Initiated Cascade Reactions
Y Ping, Y Li, J Zhu, W Kong - … Chemie International Edition, 2019 - Wiley Online Library
The enantioselective synthesis of molecules containing quaternary stereocenters is a field of
intense research interest and development. Among the known organic transformations …
intense research interest and development. Among the known organic transformations …