Late-stage C–H functionalization offers new opportunities in drug discovery

L Guillemard, N Kaplaneris, L Ackermann… - Nature Reviews …, 2021 - nature.com
Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

Organic synthesis with the most abundant transition metal–iron: from rust to multitasking catalysts

S Rana, JP Biswas, S Paul, A Paik… - Chemical Society Reviews, 2021 - pubs.rsc.org
In industries and academic laboratories, several late transition metal-catalyzed prerequisite
reactions are widely performed during single and multistep synthesis. However, besides the …

3d transition metals for C–H activation

P Gandeepan, T Müller, D Zell, G Cera… - Chemical …, 2018 - ACS Publications
C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

[HTML][HTML] A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry

C Sambiagio, D Schönbauer, R Blieck… - Chemical Society …, 2018 - pubs.rsc.org
The present review is devoted to summarizing the recent advances (2015–2017) in the field
of metal-catalysed group-directed C–H functionalisation. In order to clearly showcase the …

Strategic evolution in transition metal-catalyzed directed C–H bond activation and future directions

S Rej, A Das, N Chatani - Coordination Chemistry Reviews, 2021 - Elsevier
In the field of C–H bond functionalization chemistry, directed C–H bond activation strategies
are highly appreciated due to the high efficiency and selectivity of such reactions towards a …

Palladium/norbornene cooperative catalysis

J Wang, G Dong - Chemical reviews, 2019 - ACS Publications
Palladium/norbornene cooperative catalysis has emerged as a distinct approach to
construct polyfunctionalized arenes from readily available starting materials. This Review …

Transient directing groups for transformative C–H activation by synergistic metal catalysis

P Gandeepan, L Ackermann - Chem, 2018 - cell.com
The development of methods for the functionalization of otherwise inert C–H bonds is one of
the major foci in molecular syntheses. Recent advances have significantly improved the …

Metal–organic cooperative catalysis in C–H and C–C bond activation

DS Kim, WJ Park, CH Jun - Chemical Reviews, 2017 - ACS Publications
Transition-metal-catalyzed activation of C–H and C–C bonds is a challenging area in
synthetic organic chemistry. Among various methods to accomplish these processes, the …

Accessing Remote meta‐ and para‐C(sp2)−H Bonds with Covalently Attached Directing Groups

A Dey, SK Sinha, TK Achar… - Angewandte Chemie …, 2019 - Wiley Online Library
Directing group assisted ortho‐C− H activation has been known for the last few decades. In
contrast, extending the same approach to achieve activation of the distal meta‐and para‐C …

Construction of Quaternary Stereocenters by Palladium‐Catalyzed Carbopalladation‐Initiated Cascade Reactions

Y Ping, Y Li, J Zhu, W Kong - … Chemie International Edition, 2019 - Wiley Online Library
The enantioselective synthesis of molecules containing quaternary stereocenters is a field of
intense research interest and development. Among the known organic transformations …