Early-stage Alzheimer disease: getting trial-ready
PS Aisen, GA Jimenez-Maggiora, MS Rafii… - Nature Reviews …, 2022 - nature.com
Slowing the progression of Alzheimer disease (AD) might be the greatest unmet medical
need of our time. Although one AD therapeutic has received a controversial accelerated …
need of our time. Although one AD therapeutic has received a controversial accelerated …
Inclusion and diversity in clinical trials: actionable steps to drive lasting change
MD Kelsey, B Patrick-Lake, R Abdulai… - Contemporary Clinical …, 2022 - Elsevier
Background Improving diversity in clinical trials is essential in order to produce
generalizable results. Although the importance of representation has become increasingly …
generalizable results. Although the importance of representation has become increasingly …
Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial
In the coronavirus efficacy (COVE) phase 3 clinical trial, vaccine recipients were assessed
for neutralizing and binding antibodies as correlates of risk for COVID-19 disease and as …
for neutralizing and binding antibodies as correlates of risk for COVID-19 disease and as …
The NIH-led research response to COVID-19
F Collins, S Adam, C Colvis, E Desrosiers… - Science, 2023 - science.org
Though the COVID-19 pandemic, which has claimed the lives of at least 6.5 million
individuals worldwide, is not yet over, it is not too soon to consider the strengths and …
individuals worldwide, is not yet over, it is not too soon to consider the strengths and …
Drug combinations as a first line of defense against coronaviruses and other emerging viruses
The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made developing …
equipped for future pandemics. While unprecedented strides have been made developing …
Enhancing diversity of clinical trial populations in multiple sclerosis
RA Marrie, J Chataway, BE Bierer… - Multiple Sclerosis …, 2023 - journals.sagepub.com
Background: Demographic characteristics, social determinants of health (SDoH), health
inequities, and health disparities substantially influence the general and disease-specific …
inequities, and health disparities substantially influence the general and disease-specific …
Rapid development of an integrated network infrastructure to conduct phase 3 COVID-19 vaccine trials
Importance The COVID-19 pandemic has caused millions of infections and deaths and
resulted in unprecedented international public health social and economic crises. As SARS …
resulted in unprecedented international public health social and economic crises. As SARS …
[HTML][HTML] A framework for setting enrollment goals to ensure participant diversity in sponsored clinical trials in the United States
MR Cullen, AR Lemeshow, S Amaro… - Contemporary Clinical …, 2023 - Elsevier
Background Diversity in clinical trials (CTs) has the potential to improve health equity and
close health disparities. Underrepresentation of historically underserved groups …
close health disparities. Underrepresentation of historically underserved groups …
Proactive strategies to optimize engagement of Black, Hispanic/Latinx, transgender, and nonbinary individuals in a trial of a novel agent for HIV pre-exposure …
M Cespedes, M Das, JC Hojilla, J Blumenthal… - PloS one, 2022 - journals.plos.org
Introduction Black and Hispanic/Latinx cisgender men who have sex with men (MSM),
transgender women, transgender men, and gender nonbinary (TGNB) individuals have …
transgender women, transgender men, and gender nonbinary (TGNB) individuals have …
Improving COVID-19 vaccine uptake among Black populations: a systematic review of strategies
M Adeagbo, M Olukotun, S Musa, D Alaazi… - International Journal of …, 2022 - mdpi.com
Given the growing body of evidence on COVID-19 vaccine hesitancy among Black
populations, the aim of this systematic review was to identify the interventions and strategies …
populations, the aim of this systematic review was to identify the interventions and strategies …