The host response to naturally-derived extracellular matrix biomaterials

AH Morris, DK Stamer, TR Kyriakides - Seminars in immunology, 2017 - Elsevier
Biomaterials based on natural materials including decellularized tissues and tissue-derived
hydrogels are becoming more widely used for clinical applications. Because of their native …

Harnessing macrophage plasticity for tissue regeneration

TD Smith, RR Nagalla, EY Chen, WF Liu - Advanced drug delivery reviews, 2017 - Elsevier
Macrophages are versatile and plastic effector cells of the immune system, and contribute to
diverse immune functions including pathogen or apoptotic cell removal, inflammatory …

[HTML][HTML] Development of an accurate and proactive immunomodulatory strategy to improve bone substitute material-mediated osteogenesis and angiogenesis

Z Zheng, Y Chen, D Wu, J Wang, M Lv, X Wang… - Theranostics, 2018 - ncbi.nlm.nih.gov
Background: Treatment of large bone defects represents a major clinical problem worldwide.
Suitable bone substitute materials are commonly required to achieve successful bone …

[HTML][HTML] Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A …

L Hou, Z Zhu, F Jiang, J Zhao, Q Jia, Q Jiang… - Ecotoxicology and …, 2023 - Elsevier
Silicosis is a progressive inflammatory disease with poorly defined mechanisms and limited
therapeutic options. Recent studies found that microRNAs (miRNAs) and circular RNAs …

[HTML][HTML] Focus: genome editing: therapeutic peptide nucleic acids: principles, limitations, and opportunities

E Quijano, R Bahal, A Ricciardi… - The Yale journal of …, 2017 - ncbi.nlm.nih.gov
Since their invention in 1991, peptide nucleic acids (PNAs) have been used in a myriad of
chemical and biological assays. More recently, peptide nucleic acids have also been …

miRNAs in tuberculosis: new avenues for diagnosis and host-directed therapy

N Sabir, T Hussain, SZA Shah, A Peramo… - Frontiers in …, 2018 - frontiersin.org
Tuberculosis (TB) is one of the most fatal infectious diseases and a leading cause of
mortality, with 95% of these deaths occurring in developing countries. The causative agent …

Non-viral nanocarriers for intracellular delivery of microRNA therapeutics

Z Bai, J Wei, C Yu, X Han, X Qin, C Zhang… - Journal of Materials …, 2019 - pubs.rsc.org
MicroRNAs are small regulatory noncoding RNAs that regulate various biological processes
associated with neurological disorders, cardiovascular diseases, cancer and viral infection …

microRNAs as novel therapeutics in cancer

G Romano, M Acunzo, P Nana-Sinkam - Cancers, 2021 - mdpi.com
Simple Summary Over the last few years, we have witnessed incredible advancements in
anti-tumor drug development. microRNAs, a class of small non-coding RNAs dysregulated …

Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation

AL Silva, C Peres, J Conniot, AI Matos, L Moura… - Seminars in …, 2017 - Elsevier
Nanotechnology-based strategies can dramatically impact the treatment, prevention and
diagnosis of a wide range of diseases. Despite the unprecedented success achieved with …

Non-viral based miR delivery and recent developments

AE Labatut, G Mattheolabakis - European Journal of Pharmaceutics and …, 2018 - Elsevier
Abstract miRNAs are promising therapeutic targets or tools for the treatment of numerous
diseases, with most prominently, cancer. The inherent capacity of these short nucleic acids …