Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review

V Soleimani, PS Delghandi, SA Moallem… - Phytotherapy …, 2019 - Wiley Online Library
Milk thistle (Silybum marianum) is a medicinal plant from the Asteraceae family. Silymarin is
the major constituent of milk thistle extract and is a mixture of some flavonolignans such as …

Functional foods for health: the interrelated antioxidant and anti-inflammatory role of fruits, vegetables, herbs, spices and cocoa in humans

M Serafini, I Peluso - Current pharmaceutical design, 2016 - ingentaconnect.com
The health benefits of plant food-based diets could be related to both integrated antioxidant
and antiinflammatory mechanisms exerted by a wide array of phytochemicals present in fruit …

A randomized trial of silymarin for the treatment of nonalcoholic steatohepatitis

CW Kheong, NRN Mustapha, S Mahadeva - Clinical Gastroenterology and …, 2017 - Elsevier
Background & Aims Silymarin is a complex mixture of 6 major flavonolignans and other
minor polyphenolic compounds derived from the milk thistle plant Silybum marianum; it has …

Health Benefits of Silybum marianum: Phytochemistry, Pharmacology, and Applications

X Wang, Z Zhang, SC Wu - Journal of agricultural and food …, 2020 - ACS Publications
Silybum marianum (SM), a well-known plant used as both a medicine and a food, has been
widely used to treat various diseases, especially hepatic diseases. The seeds and fruits of …

Mechanistic insights into the pharmacological significance of silymarin

K Wadhwa, R Pahwa, M Kumar, S Kumar, PC Sharma… - Molecules, 2022 - mdpi.com
Medicinal plants are considered the reservoir of diverse therapeutic agents and have been
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …

Natural products to counteract the epidemic of cardiovascular and metabolic disorders

B Waltenberger, A Mocan, K Šmejkal, EH Heiss… - Molecules, 2016 - mdpi.com
Natural products have always been exploited to promote health and served as a valuable
source for the discovery of new drugs. In this review, the great potential of natural …

The food plant Silybum marianum (L.) Gaertn.: Phytochemistry, Ethnopharmacology and clinical evidence

I Marmouzi, A Bouyahya, SM Ezzat, M El Jemli… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Silybum marianum (L.) Gaertn. or Milk thistle is a
medicinal plant native to Northern Africa, Southern Europe, Southern Russia and Anatolia. It …

Silymarin: a review on paving the way towards promising pharmacological agent

MN Akhtar, R Saeed, F Saeed, A Asghar… - … Journal of Food …, 2023 - Taylor & Francis
Advancements in the field of research and development have paved toward the use of
herbal agents to cure and control health maladies. Milk thistle (Silybum marianum L.) is one …

Solid lipid nanoparticles for delivery of andrographolide across the blood-brain barrier: in vitro and in vivo evaluation

G Graverini, V Piazzini, E Landucci, D Pantano… - Colloids and Surfaces B …, 2018 - Elsevier
Andrographolide is a major diterpenoid of Andrographis paniculata and possesses several
biological activities, including protection against oxidative stress mediated neurotoxicity …

Targeting inflammation by flavonoids: novel therapeutic strategy for metabolic disorders

MH Farzaei, AK Singh, R Kumar, CR Croley… - International journal of …, 2019 - mdpi.com
A balanced metabolic profile is essential for normal human physiological activities.
Disproportions in nutrition give rise to imbalances in metabolism that are associated with …