Background: Electronic cigarette (e-cigarette) use has increased substantially in recent
years. While e-cigarettes have been proposed as a potentially effective smoking cessation …

A number of studies have assessed the effects of psychoactive drugs on stress biology, the
neuroadaptations resulting from chronic drug use on stress biology, and their effects on …

Background—Smoking is an important cardiovascular disease risk factor, but the
mechanisms linking smoking to blood pressure are poorly understood. Methods and Results …

Background Substantial variability exists in therapeutic response and adverse effects with
pharmacotherapies for tobacco dependence. Biomarkers to optimise treatment choice for …

The cytochrome P450 2A6 (CYP2A6) enzyme metabolizes several clinically relevant
substrates, including nicotine—the primary psychoactive component in cigarette smoke. The …

Abstract Rationale The Drug Effects Questionnaire (DEQ) is widely used in studies of acute
subjective response (SR) to a variety of substances, but the format of the DEQ varies widely …

Objective Insomnia is a clinically verified nicotine withdrawal symptom. As nicotine is a
stimulant, it is plausible that smoking at night could disturb sleep more than smoking at …

Background: The ratio of 3′ hydroxycotinine to cotinine, or nicotine metabolite ratio (NMR),
is strongly associated with CYP2A6 genotype, CYP2A6-mediated nicotine and cotinine …

Introduction: To determine the effect of ovarian hormones on smoking, we conducted a
systematic review of menstrual cycle effects on smoking (ie, ad lib smoking, smoking …

Background Tobacco products containing menthol are widely used by youth. We used e-
cigarettes to conduct an experimental evaluation of the independent and interactive effects …