[HTML][HTML] G protein-coupled receptors: structure-and function-based drug discovery
D Yang, Q Zhou, V Labroska, S Qin… - Signal transduction and …, 2021 - nature.com
As one of the most successful therapeutic target families, G protein-coupled receptors
(GPCRs) have experienced a transformation from random ligand screening to knowledge …
(GPCRs) have experienced a transformation from random ligand screening to knowledge …
Treatment of type 2 diabetes: challenges, hopes, and anticipated successes
MA Nauck, J Wefers, JJ Meier - The lancet Diabetes & endocrinology, 2021 - thelancet.com
Despite the successful development of new therapies for the treatment of type 2 diabetes,
such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose …
such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose …
[HTML][HTML] Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling
SE Anton, C Kayser, I Maiellaro, K Nemec, J Möller… - Cell, 2022 - cell.com
G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …
[HTML][HTML] Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist
FS Willard, JD Douros, MBN Gabe, AD Showalter… - JCI insight, 2020 - ncbi.nlm.nih.gov
Tirzepatide (LY3298176) is a dual GIP and GLP-1 receptor agonist under development for
the treatment of type 2 diabetes mellitus (T2DM), obesity, and nonalcoholic steatohepatitis …
the treatment of type 2 diabetes mellitus (T2DM), obesity, and nonalcoholic steatohepatitis …
[HTML][HTML] GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics
G protein-coupled receptors are important drug targets that engage and activate signaling
transducers in multiple cellular compartments. Delineating therapeutic signaling from …
transducers in multiple cellular compartments. Delineating therapeutic signaling from …
Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery
Oral drug administration remains the preferred route for patients and health care providers.
Delivery of macromolecules through this route remains challenging because of limitations …
Delivery of macromolecules through this route remains challenging because of limitations …
Conserved class B GPCR activation by a biased intracellular agonist
LH Zhao, Q He, Q Yuan, Y Gu, X He, H Shan, J Li… - Nature, 2023 - nature.com
Class B G-protein-coupled receptors (GPCRs), including glucagon-like peptide 1 receptor
(GLP1R) and parathyroid hormone 1 receptor (PTH1R), are important drug targets …
(GLP1R) and parathyroid hormone 1 receptor (PTH1R), are important drug targets …
[HTML][HTML] Differential GLP-1R binding and activation by peptide and non-peptide agonists
Peptide drugs targeting class B1 G-protein-coupled receptors (GPCRs) can treat multiple
diseases; however, there remains substantial interest in the development of orally delivered …
diseases; however, there remains substantial interest in the development of orally delivered …
Membranes under the magnetic lens: a dive into the diverse world of membrane protein structures using Cryo-EM
Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …
present different challenges for structure determination. They are biologically important for …
New insights into the structure and function of class B1 GPCRs
G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors. Class
B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large …
B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large …