Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease,
manifested by syncope or sudden death in children or young adults under stress conditions …

Aims In cardiac muscle, phosphorylation of the RyRs is proposed to increase their Ca 2+
sensitivity. This mechanism could be arrhythmogenic via facilitation of spontaneous Ca 2+ …

Mutations of the RyR2 are channelopathies that can predispose to life threatening
catecholaminergic polymorphic ventricular tachycardias (CPVTs) during exercise or stress …

Abstract Analysis of Ca 2+ signals obtained in various cell types (ie, cardiomyocytes) is
always a tradeoff between acquisition speed and signal/noise ratio of the fluorescence …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent calcium ion (Ca
2+) activating second messenger due to its ability to release Ca 2+ from intracellular acidic …

Pulsed power treatment has been used to induce regulated cell death (RCD) in cells or
ablate tumors in animals. A subset of pulsed power as electroporation with high voltage and …

An increase in the cytosolic Ca 2+ concentration triggers the contraction in cardiomyocytes.
In these cells sarcoplasmic reticulum (SR) is the major source of Ca 2+, and the release from …

Human cardiac ryanodine receptors (hRyR2) are calcium (Ca2+) release channels central
to excitation-contraction coupling. Mutations in hRyR2 are linked to catecholaminergic …