Impaired binding to junctophilin-2 and nanostructural alteration in CPVT mutation
L Yin, A Zahradnikova Jr, R Rizzetto… - Circulation …, 2021 - Am Heart Assoc
Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease,
manifested by syncope or sudden death in children or young adults under stress conditions …
manifested by syncope or sudden death in children or young adults under stress conditions …
Stabilization of Ca2+ signaling in cardiac muscle by stimulation of SERCA
M Fernandez-Tenorio, E Niggli - Journal of molecular and cellular …, 2018 - Elsevier
Aims In cardiac muscle, phosphorylation of the RyRs is proposed to increase their Ca 2+
sensitivity. This mechanism could be arrhythmogenic via facilitation of spontaneous Ca 2+ …
sensitivity. This mechanism could be arrhythmogenic via facilitation of spontaneous Ca 2+ …
[HTML][HTML] Uptake-leak balance of SR Ca2+ determines arrhythmogenic potential of RyR2R420Q+/− cardiomyocytes
R Lopez, R Janicek, M Fernandez-Tenorio… - Journal of molecular and …, 2022 - Elsevier
Mutations of the RyR2 are channelopathies that can predispose to life threatening
catecholaminergic polymorphic ventricular tachycardias (CPVTs) during exercise or stress …
catecholaminergic polymorphic ventricular tachycardias (CPVTs) during exercise or stress …
Automatic detection and classification of Ca2+ release events in line-and frame-scan images
A Illaste, M Wullschleger, M Fernandez-Tenorio… - Biophysical journal, 2019 - cell.com
Abstract Analysis of Ca 2+ signals obtained in various cell types (ie, cardiomyocytes) is
always a tradeoff between acquisition speed and signal/noise ratio of the fluorescence …
always a tradeoff between acquisition speed and signal/noise ratio of the fluorescence …
Role of calcium mobilising messengers in cardiac arrhythmias
R Bin Abdul Mu-u-min - 2019 - ora.ox.ac.uk
Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent calcium ion (Ca
2+) activating second messenger due to its ability to release Ca 2+ from intracellular acidic …
2+) activating second messenger due to its ability to release Ca 2+ from intracellular acidic …
Nanosecond Pulsed Electric Field Modulates Electron Transport and Mitochondrial Structure and Function
LN Potter - 2023 - search.proquest.com
Pulsed power treatment has been used to induce regulated cell death (RCD) in cells or
ablate tumors in animals. A subset of pulsed power as electroporation with high voltage and …
ablate tumors in animals. A subset of pulsed power as electroporation with high voltage and …
Simultaneous Recording of Subcellular Ca2+ Signals from the Cytosol and Sarco/Endoplasmic Reticulum: Compartmentalized Dye Loading, Imaging, and Analysis
E Niggli, M Fernandez-Tenorio - Calcium-Binding Proteins of the EF-Hand …, 2019 - Springer
An increase in the cytosolic Ca 2+ concentration triggers the contraction in cardiomyocytes.
In these cells sarcoplasmic reticulum (SR) is the major source of Ca 2+, and the release from …
In these cells sarcoplasmic reticulum (SR) is the major source of Ca 2+, and the release from …
Functional heterogeneity of CPVT-mutant human cardiac ryanodine receptors: evaluation of the influence of S2031 and S2808 phosphorylation sites
S Hamilton - 2017 - orca.cardiff.ac.uk
Human cardiac ryanodine receptors (hRyR2) are calcium (Ca2+) release channels central
to excitation-contraction coupling. Mutations in hRyR2 are linked to catecholaminergic …
to excitation-contraction coupling. Mutations in hRyR2 are linked to catecholaminergic …
[引用][C] Моделювання впливу лікарських препаратів на функціональну активність серцевих клітин
Д Дмитренок - 2023 - КПІ ім. Ігоря Сікорського