Immune responses in diabetic nephropathy: Pathogenic mechanisms and therapeutic target

J Chen, Q Liu, J He, Y Li - Frontiers in Immunology, 2022 - frontiersin.org
Diabetic nephropathy (DN) is a chronic, inflammatory disease affecting millions of diabetic
patients worldwide. DN is associated with proteinuria and progressive slowing of glomerular …

Emerging roles for microRNAs in diabetic microvascular disease: novel targets for therapy

Y Zhang, X Sun, B Icli, MW Feinberg - Endocrinology Reviews, 2017 - academic.oup.com
Chronic, low-grade systemic inflammation and impaired microvascular function are critical
hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major …

Diabetic nephropathy: new insights into established therapeutic paradigms and novel molecular targets

D Sharma, P Bhattacharya, K Kalia, V Tiwari - Diabetes Research and …, 2017 - Elsevier
Diabetic nephropathy is one of the most prevalent microvascular complication in patients
suffering from diabetes and is reported to be the major cause of renal failure when …

[HTML][HTML] Triptolide attenuates renal tubular epithelial-mesenchymal transition via the MiR-188-5p-mediated PI3K/AKT pathway in diabetic kidney disease

M Xue, Y Cheng, F Han, Y Chang, Y Yang… - … Journal of Biological …, 2018 - ncbi.nlm.nih.gov
Triptolide possesses the trait of renal protection. Epithelial-mesenchymal transition (EMT) is
closely linked to the pathogenesis of diabetic kidney disease (DKD). MicroRNAs have …

miRNAs in urine extracellular vesicles as predictors of early‐stage diabetic nephropathy

Y Jia, M Guan, Z Zheng, Q Zhang… - Journal of diabetes …, 2016 - Wiley Online Library
Background. miR‐192, miR‐194, and miR‐215 are enriched in the kidney and play roles in
the pathogenesis of diabetic nephropathy (DN). Extracellular vesicles (EVs) can be detected …

The circulating exosomal microRNAs related to albuminuria in patients with diabetic nephropathy

H Kim, YU Bae, JS Jeon, H Noh, HK Park… - Journal of translational …, 2019 - Springer
Background Diabetic nephropathy (DN) is associated with high risk of cardiovascular
disease and mortality. Exosomal microRNAs (miRNAs) regulate gene expression in a …

Role of microRNA 21 in diabetes and associated/related diseases

D Sekar, B Venugopal, P Sekar, K Ramalingam - Gene, 2016 - Elsevier
Diabetes mellitus (DM) is a disease related to metabolic disorder and becoming an
epidemic in developing countries. Current treatments for DM include modified lifestyle …

Circ_0080425 inhibits cell proliferation and fibrosis in diabetic nephropathy via sponging miR‐24‐3p and targeting fibroblast growth factor 11

H Liu, X Wang, ZY Wang, L Li - Journal of cellular physiology, 2020 - Wiley Online Library
Diabetic nephropathy (DN) is a severe end‐stage kidney disease developed from diabetes
mellitus. The involvement of circular RNAs (circRNAs) in modulating DN pathogenesis has …

Urinary exosomal microRNA-451-5p is a potential early biomarker of diabetic nephropathy in rats

A Mohan, RS Singh, M Kumari, D Garg, A Upadhyay… - PloS one, 2016 - journals.plos.org
Non-invasive renal signatures can help in serial monitoring of diabetic patients. We tested
whether urinary exosomal (UE) microRNA (miR) analysis could non-invasively predict renal …

The role of microRNA in the pathogenesis of diabetic nephropathy

J Szostak, A Gorący, D Durys, P Dec… - International Journal of …, 2023 - mdpi.com
Diabetic nephropathy is one of the most common and severe complications of diabetes
mellitus, affecting one in every five patients suffering from diabetes. Despite extensive …