This review gives an overview of the protective role of CD8+ T cells in SARS-CoV-2
infection. The cross-reactive responses intermediated by CD8+ T cells in unexposed cohorts …

Although mRNA vaccine efficacy against severe coronavirus disease 2019 remains high,
variant emergence has prompted booster immunizations. However, the effects of repeated …

T cell responses play an important role in protection against beta-coronavirus infections,
including SARS-CoV-2, where they associate with decreased COVID-19 disease severity …

There is an urgent need for new generation anti-SARS-Cov-2 vaccines in order to increase
the efficacy of immunization and its broadness of protection against viral variants that are …

Abstract SARS-CoV-2 mRNA vaccines, including Pfizer/Biontech BNT162b2, were shown to
be effective for COVID-19 prevention, eliciting both robust antibody responses in naive …

Background The mutations in SARS-CoV-2 variants of concern (VOC) facilitate the virus'
escape from the neutralizing antibodies induced by vaccines. However, the protection from …

Introduction COVID-19 vaccines based on mRNA have represented a revolution in the
biomedical research field. The initial two-dose vaccination schedule generates potent …

SARS-CoV-2 variants of concern have emerged since the COVID-19 outburst, notably the
lineages detected in the UK, South Africa, and Brazil. Their increased transmissibility and …

The effectiveness of the antiviral immune response largely depends on the activation of
cytotoxic T cells. The heterogeneous group of functionally active T cells expressing the …

Single-cell RNA sequencing (scRNA-Seq) studies have provided critical insight into the
pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the …