Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness
Proteasomes are the central proteolytic machines that are critical for breaking down most of
the damaged and abnormal proteins in human cells. Although universally applicable drugs …
the damaged and abnormal proteins in human cells. Although universally applicable drugs …
Transcriptional regulatory networks of the proteasome in mammalian systems
M Kapetanou, S Athanasopoulou, ES Gonos - IUBMB life, 2022 - Wiley Online Library
The tight regulation of proteostasis is essential for physiological cellular function.
Mammalian cells possess a network of mechanisms that ensure proteome integrity under …
Mammalian cells possess a network of mechanisms that ensure proteome integrity under …
[HTML][HTML] Pan-cancer analysis identifies proteasome 26S subunit, ATPase (PSMC) family genes, and related signatures associated with prognosis, immune profile, and …
H Jia, WJ Tang, L Sun, C Wan, Y Zhou… - Frontiers in …, 2023 - frontiersin.org
Background: Proteasome 26S subunit, ATPase gene (PSMC) family members play a critical
role in regulating protein degradation and are essential for tumor development. However …
role in regulating protein degradation and are essential for tumor development. However …
UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage
X Hu, R Zou, Z Zhang, J Ji, J Li, XY Huo, D Liu… - … et Biophysica Acta (BBA …, 2023 - Elsevier
The transcription factor nuclear factor erythroid 2 like 1 (NFE2L1 or NRF1) regulates
constitutive and inducible expression of proteasome subunits and assembly chaperones …
constitutive and inducible expression of proteasome subunits and assembly chaperones …
Upregulation of immunoproteasome PSMB8 is associated with Parkinson's disease
HD Nguyen, YE Kim, LTN Nguyen, IH Kwak… - Parkinsonism & Related …, 2023 - Elsevier
Background Immunoproteasome, a part of ubiquitin–proteasome system, is involved in
immune response as well as protein degradation. However, the relationship between …
immune response as well as protein degradation. However, the relationship between …
[HTML][HTML] Proteomic characterization of dry blood spots of healthy women during simulation the microgravity effects using dry immersion
DN Kashirina, AG Brzhozovskiy, W Sun… - Frontiers in …, 2022 - frontiersin.org
Dry immersion (DI) is one of the most widely used terrestrial microgravity models. Dry
immersion accurately and quickly reproduces most of the physiological effects of the early …
immersion accurately and quickly reproduces most of the physiological effects of the early …
[HTML][HTML] Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates
S Kim, SH Park, WH Choi, MJ Lee - Immune Network, 2022 - ncbi.nlm.nih.gov
The 26S proteasome irreversibly hydrolyzes polyubiquitylated substrates to maintain protein
homeostasis; it also regulates immune responses by generating antigenic peptides. An …
homeostasis; it also regulates immune responses by generating antigenic peptides. An …
[HTML][HTML] Oleuropein activates neonatal neocortical proteasomes, but proteasome gene targeting by AAV9 is variable in a clinically relevant piglet model of brain …
N El Demerdash, MW Chen, CE O'brien, S Adams… - Cells, 2021 - mdpi.com
Cerebral hypoxia-ischemia (HI) compromises the proteasome in a clinically relevant
neonatal piglet model. Protecting and activating proteasomes could be an adjunct therapy to …
neonatal piglet model. Protecting and activating proteasomes could be an adjunct therapy to …
Integrated proteomics spotlight the proteasome as a therapeutic vulnerability in embryonal tumors with multilayered rosettes
M Dottermusch, A Biabani, T Lempertz… - Neuro …, 2024 - academic.oup.com
Background Embryonal tumors with multilayered rosettes (ETMR) are rare malignant
embryonal brain tumors. The prognosis of ETMR is poor and novel therapeutic approaches …
embryonal brain tumors. The prognosis of ETMR is poor and novel therapeutic approaches …
A Computational Approach for Exploring Indinavir as a Potent Protease Inhibitor and Development of Its Microsphere for Anticancer Activity
Purpose The objective of the present investigation was to establish a molecular association
of different proteases as cancer targets with the indinavir and how the physicochemical …
of different proteases as cancer targets with the indinavir and how the physicochemical …