Neural stem cells exist not only in the developing mammalian nervous system but also in the
adult nervous system of all mammalian organisms, including humans. Neural stem cells can …

Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and
astrocytes constitute macroglia. This review deals with the recent progress related to the …

We tested the feasibility and safety of human-spinal-cord-derived neural stem cell (NSI-566)
transplantation for the treatment of chronic spinal cord injury (SCI). In this clinical trial, four …

Abstract Treatment of brain injury with exosomes derived from mesenchymal stromal cells
(MSCs) enhances neurite growth. However, the direct effect of exosomes on axonal growth …

The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster
within regions enriched for genes encoding developmentally important transcription factors …

Remyelination involves reinvesting demyelinated axons with new myelin sheaths. In stark
contrast to the situation that follows loss of neurons or axonal damage, remyelination in the …

The remarkable developmental potential and replicative capacity of human embryonic stem
(ES) cells promise an almost unlimited supply of specific cell types for transplantation …

The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

We describe here the isolation of stem cells from juvenile and adult rodent skin. These cells
derive from the dermis, and clones of individual cells can proliferate and differentiate in …

This review summarizes the current understanding of spinal cord injury pathophysiology and
discusses important emerging regenerative approaches that have been translated into …