Inflammasomes are multiprotein complexes that can sense danger signals and activate
caspase-1 to mediate pro-inflammatory cytokines release and pyroptotic cell death. There …

Alcohol-associated liver disease (ALD) comprises a spectrum of liver diseases that include:
steatosis to alcohol-associated hepatitis, cirrhosis, and ultimately hepatocellular carcinoma …

Oxidative stress and its associated lipid peroxidation play a key role in nonalcoholic
steatohepatitis (NASH). Ferroptosis is a recently recognized type of cell death characterized …

Purpose Chronic kidney disease (CKD) is a global nephrotic syndrome characterized by
chronic inflammation, oxidative stress and fibrosis in the kidney. Isoliquiritigenin (ISL), a …

Neuroinflammatory processes mediated by microglial activation and subsequent neuronal
damage are the hallmarks of traumatic brain injury (TBI). As an inhibitor of the macrophage …

Alcohol-associated liver disease (ALD) is one of the major diseases arising from chronic
alcohol consumption and is one of the most common causes of liver-related morbidity and …

Background and aims: Saikosaponin d (SSd) has a steroidal structure and significant anti-
inflammatory effects. The purpose of this study was to explore the mechanism underlying …

Alcoholic liver disease is one of the most prevalent chronic diseases that causes high
morbidity and mortality worldwide. This study demonstrated the protective potential of …

Tubules injury and immune cell activation are the common pathogenic mechanisms in acute
kidney injury (AKI). However, the exact modes of immune cell activation following tubule …

Microglia are the resident immune cells of the central nervous system (CNS) and play a key
role in neurological diseases, including intracerebral hemorrhage (ICH). Microglia are …