The trabecular meshwork (TM) is located in the anterior segment of the eye and is
responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous …

The glomerular basement membrane (GBM) is an important component of the kidney's
glomerular filtration barrier. Like all basement membranes, the GBM contains type IV …

Eye formation is the result of coordinated induction and differentiation processes during
embryogenesis. Disruption of any one of these events has the potential to cause ocular …

Background Recent clinical whole exome sequencing (WES) cohorts have identified
unanticipated multiple genetic diagnoses in single patients. However, the frequency of …

Basement membranes (BMs), a specialized form of extracellular matrix, underlie nearly all
cell layers and provide structural support for tissues and interact with cell surface receptors …

Deletions at chromosome 2p25. 3 are associated with a syndrome consisting of intellectual
disability and obesity. The smallest region of overlap for deletions at 2p25. 3 contains PXDN …

Basement membranes are highly specialized extracellular matrices. Once considered inert
scaffolds, basement membranes are now viewed as dynamic and versatile environments …

Basement membranes are thin strong sheets of extracellular matrix. They provide
mechanical and biochemical support to epithelia, muscles, nerves, and blood vessels …

Recently, growing attention has been directed toward stem cell metabolism, with the key
observation that the plasticity of stem cells also reflects the plasticity of their energy substrate …

Primary open-angle glaucoma (POAG) is a genetically, physiologically, and phenotypically
complex neurodegenerative disorder. This study addressed the expanding collection of …