Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder and the most common
motor neuron disease. ALS shows substantial clinical and molecular heterogeneity. In vitro …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by upper and lower motor neuron loss. The pathomechanisms of ALS are still …

Frontotemporal dementia is a clinically, genetically and pathologically heterogeneous
neurodegenerative disorder, enclosing a wide range of different pathological entities …

Volume 7 of Advances in Clinical Chemistry ranges over the whole gamut of the subject. The
broad scope presented here is a deliberate act of policy-the aim is to emphasize the …

Objective Although metabolic abnormalities are implicated in the etiology of
neurodegenerative diseases, their role in the development of amyotrophic lateral sclerosis …

The MFN2 gene encodes mitofusin 2, a key protein for mitochondrial fusion, transport,
maintenance and cell communication. MFN2 mutations are primarily linked to Charcot …

The abnormal expansion of G-rich hexanucleotide repeat, GGGGCC (G4C2), in
chromosome 9 open reading frame 72 (C9orf72) is known to be the prevailing genetic cause …

Amyotrophic lateral sclerosis (ALS) is a relatively rare but fatal neurodegenerative disease
with the progressive loss of both upper and lower motor neurons. Although …

ALS and FTD are complex neurodegenerative disorders that primarily affects motor neurons
in the brain and spinal cord, and cortical neurons in the frontal lobe. Although the …

Frontotemporal dementia (FTD) is the second most common cause of dementia in patients
under 65 years, characterized by diverse clinical symptoms, neuropathologies, and genetic …