Vitamin A and its derivatives, retinoids, have been widely studied for their use as cancer
chemotherapeutic agents. With respect to colorectal cancer (CRC), several critical mutations …

Although the zebrafish was initially developed as a model system to study embryonic
development, it has gained increasing attention as an advantageous system to investigate …

Aberrant Wnt/β-catenin signaling following loss of the tumor suppressor adenomatous
polyposis coli (APC) is thought to initiate colon adenoma formation. Using zebrafish and …

Most in vitro toxicity studies on engineered nanomaterials (ENMs) use transformed rather
than primary cells for logistical reasons. However, primary cells may provide a more …

Although genome-wide hypomethylation is a hallmark of many cancers, roles for active DNA
demethylation during tumorigenesis are unknown. Here, loss of the APC tumor suppressor …

Kidney formation involves patterning events that induce renal progenitors to form nephrons
with an intricate composition of multiple segments. Here, we performed a chemical genetic …

We previously demonstrated that RARα2 expression is increased in CD138 selected plasma
cells of relapsed multiple myelomas (MMs), and increased expression was linked to poor …

Both the tumour growth and progression and the systemic inflammatory response have the
potential to increase oxidative stress. We therefore examined the relationship between lipid …

Colorectal cancer (CRC) was ranked third in morbidity and mortality in the United States in
2013. Although substantial progress has been made in surgical techniques and …

The liver is an essential organ that plays a pivotal role in metabolism, digestion and nutrient
storage. Major efforts have been made to develop zebrafish (Danio rerio) as a model system …