Over 30 nitrile-containing pharmaceuticals are prescribed for a diverse variety of medicinal
indications with more than 20 additional nitrile-containing leads in clinical development …

In recent years, many compounds having potent antiviral activity in cell culture have been
detected and some of these compounds are currently undergoing either preclinical or …

Background Female-initiated HIV-prevention options, such as microbicides, are urgently
needed. We assessed Carraguard, a carrageenan-based compound developed by the …

Abstract Background Human rhinoviruses (HRVs) are the predominant cause of common
cold. In addition, HRVs are implicated in the worsening of COPD and asthma, as well as the …

Herpes simplex virus types 1 and 2 (HSV-1, HSV-2) infections are common, but can cause
serious infections in neonates and the immunocompromised. Drugs currently used to treat …

Infection by the human immunodeficiency virus type 1 (HIV-1) is an ordered, multistep
process involving binding and entry, reverse transcription, integration, viral gene …

Microbicides represent a potential intervention strategy for preventing HIV transmission.
Vaginal microbicides would meet the need for a discreet method that women could use to …

Targeting Trojan Horse leukocytes for HIV prevention : AIDS Targeting Trojan Horse leukocytes
for HIV prevention : AIDS Log in or Register Subscribe to journalSubscribe Get new issue …

Infection with human immunodeficiency virus (HIV) remains a global public health concern
and is particularly serious in low-and middle-income countries. Widespread sexual violence …

The discovery of the human immunodeficiency virus type 1 (HIV-1) in 1982 soon led to the
identification and development of antiviral compounds to be used in treatment strategies for …