Copper is an essential element in cells; it can act as either a recipient or a donor of
electrons, participating in various reactions. However, an excess of copper ions in cells is …

Detailed studies in the past two decades have shown that redox active metals like iron (Fe),
copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions …

Metformin is the first-line drug treatment for type 2 diabetes. Globally, over 100 million
patients are prescribed this drug annually. Metformin was discovered before the era of target …

Copper (Cu), a redox active metal, is an essential nutrient for all species studied to date.
During the past decade, there has been increasing interest in the concept that marginal …

Copper is an essential microelement that plays an important role in a wide variety of
biological processes. Copper concentration has to be finely regulated, as any imbalance in …

Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …

Cuproptosis resulting from copper (Cu) overload has not yet been investigated in diabetic
cardiomyopathy (DCM). Advanced glycosylation end products (AGEs) induced by persistent …

Copper and iron are essential but also toxic metals. Their essentiality is known, but their
toxicity, except for the genetic overload diseases, Wilson's disease and hemochromatosis, is …

Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …

Recently, cuproptosis has been demonstrated to be a new non-apototic cell death mode that
is characterized by copper dependence and the regulation of mitochondrial respiration …