The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis
The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis
MD Scofield, PW Kalivas - The Neuroscientist, 2014 - journals.sagepub.com
Addiction is characterized as a chronic relapsing disorder whereby addicted individuals
persistently engage in drug seeking and use despite profound negative consequences. The …
persistently engage in drug seeking and use despite profound negative consequences. The …
Development and evaluation of a calcium alginate based oral ceftriaxone sodium formulation
The purpose of this work was to develop a multiparticulate system exploiting the pH-
sensitive property and biodegradability of calcium alginate beads for intestinal delivery of …
sensitive property and biodegradability of calcium alginate beads for intestinal delivery of …
[HTML][HTML] Caffeine induces neurobehavioral effects through modulating neurotransmitters
F Alasmari - Saudi Pharmaceutical Journal, 2020 - Elsevier
Evidence demonstrates that chronic caffeine exposure, primarily through consumption of
coffee or tea, leads to increased alertness and anxiety. Preclinical and clinical studies …
coffee or tea, leads to increased alertness and anxiety. Preclinical and clinical studies …
Targeting glutamate uptake to treat alcohol use disorders
Alcoholism is a serious public health concern that is characterized by the development of
tolerance to alcohol's effects, increased consumption, loss of control over drinking and the …
tolerance to alcohol's effects, increased consumption, loss of control over drinking and the …
Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol …
Alteration of glutamatergic-neurotransmission is a hallmark of alcohol dependence. We
have previously reported that chronic ethanol-drinking downregulated glutamate transporter …
have previously reported that chronic ethanol-drinking downregulated glutamate transporter …
Glial and neuroinflammatory targets for treating substance use disorders
RK Bachtell, JD Jones, KG Heinzerling… - Drug and alcohol …, 2017 - Elsevier
Background The plenary session at the 2016 Behavior, Biology and Chemistry:
Translational Research in Addiction Conference focused on glia as potential players in the …
Translational Research in Addiction Conference focused on glia as potential players in the …
General pathophysiology of astroglia
Astroglial cells are involved in most if not in all pathologies of the brain. These cells can
change the morpho-functional properties in response to pathology or innate changes of …
change the morpho-functional properties in response to pathology or innate changes of …
Translational potential of astrocytes in brain disorders
Fundamentally, all brain disorders can be broadly defined as the homeostatic failure of this
organ. As the brain is composed of many different cells types, including but not limited to …
organ. As the brain is composed of many different cells types, including but not limited to …
Rat animal models for screening medications to treat alcohol use disorders
The purpose of this review is to present animal research models that can be used to screen
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …