Understanding intrinsic hematopoietic stem cell aging
E Mejia-Ramirez, MC Florian - haematologica, 2019 - pmc.ncbi.nlm.nih.gov
Hematopoietic stem cells (HSC) sustain blood production over the entire life-span of an
organism. It is of extreme importance that these cells maintain self-renewal and …
organism. It is of extreme importance that these cells maintain self-renewal and …
Quantitative single-cell proteomics as a tool to characterize cellular hierarchies
Large-scale single-cell analyses are of fundamental importance in order to capture
biological heterogeneity within complex cell systems, but have largely been limited to RNA …
biological heterogeneity within complex cell systems, but have largely been limited to RNA …
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate
L García-Prat, KB Kaufmann, F Schneiter, V Voisin… - Cell stem cell, 2021 - cell.com
It is critical to understand how human quiescent long-term hematopoietic stem cells (LT-
HSCs) sense demand from daily and stress-mediated cues and then transition into …
HSCs) sense demand from daily and stress-mediated cues and then transition into …
Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia
MM Naldini, G Casirati, M Barcella… - Nature …, 2023 - nature.com
Acute myeloid leukemia may be characterized by a fraction of leukemia stem cells (LSCs)
that sustain disease propagation eventually leading to relapse. Yet, the contribution of LSCs …
that sustain disease propagation eventually leading to relapse. Yet, the contribution of LSCs …
[HTML][HTML] Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis
Current treatments for acute myeloid leukemia (AML) are often ineffective in eliminating
leukemic stem cells (LSCs), which perpetuate the disease. Here, we performed a metabolic …
leukemic stem cells (LSCs), which perpetuate the disease. Here, we performed a metabolic …
A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness
Continuous supply of immune cells throughout life relies on the delicate balance in the
hematopoietic stem cell (HSC) pool between long-term maintenance and meeting the …
hematopoietic stem cell (HSC) pool between long-term maintenance and meeting the …
Sphingolipid modulation activates proteostasis programs to govern human hematopoietic stem cell self-renewal
Cellular stress responses serve as crucial decision points balancing persistence or culling of
hematopoietic stem cells (HSCs) for lifelong blood production. Although strong stressors cull …
hematopoietic stem cells (HSCs) for lifelong blood production. Although strong stressors cull …
Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation
Acute myeloid leukemia (AML) is a caricature of normal hematopoiesis driven from leukemia
stem cells (LSC) that share some hematopoietic stem cell (HSC) programs including …
stem cells (LSC) that share some hematopoietic stem cell (HSC) programs including …
p21-Activated kinases as promising therapeutic targets in hematological malignancies
A Wu, X Jiang - Leukemia, 2022 - nature.com
Abstract The p21-Activated Kinases (PAKs) are a family of six serine/threonine kinases that
were originally identified as downstream effectors of the Rho GTPases Cdc42 and Rac …
were originally identified as downstream effectors of the Rho GTPases Cdc42 and Rac …
A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome
H Boutzen, SA Madani Tonekaboni, M Chan-Seng-Yue… - Leukemia, 2022 - nature.com
Many cancers are organized as cellular hierarchies sustained by cancer stem cells (CSC),
whose eradication is crucial for achieving long-term remission. Difficulties to isolate and …
whose eradication is crucial for achieving long-term remission. Difficulties to isolate and …