Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic
apoptosis, regulates physiological cell death and pathological tissue degeneration. Its …

As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or
mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress …

Heart disease remains the leading cause of death and disability in the Western world.
Current therapies aim at treating the symptoms rather than the subcellular mechanisms …

Abstract Intracellular calcium (Ca 2+) is a critical coordinator of various aspects of cellular
physiology. It is increasingly apparent that changes in cellular Ca 2+ dynamics contribute to …

The microRNAs miR-1 and miR-133 are preferentially expressed in cardiac and skeletal
muscles and have been shown to regulate differentiation and proliferation of these cells. We …

The various splice variants of the three SERCA-and the two SPCA-pump genes in higher
vertebrates encode P-type ATPases of the P2A group found respectively in the membranes …

Abstract Background Ischemic postconditioning (IPost) has aroused much attention since
2003 when it was firstly reported. The role of microRNAs (miRNAs or miRs) in IPost has …

Early studies describing the endocytic–exocytic cycling of integrins prompted proposals that
this process regulates cell migration. However, it is only relatively recently that more detailed …

Oxidative stress is a causal factor and key promoter of a variety of cardiovascular diseases
associated with apoptotic cell death by causing deregulation of related genes. Though …

Apoptosis is a tightly regulated, cell deletion process that plays an important role in various
cardiovascular diseases, such as myocardial infarction, reperfusion injury, and heart failure …