Pericytes and neurovascular function in the healthy and diseased brain
Pericytes are multi-functional cells embedded within the walls of capillaries throughout the
body, including the brain. Pericytes were first identified in the 1870s, but little attention was …
body, including the brain. Pericytes were first identified in the 1870s, but little attention was …
Brain microvascular pericytes in vascular cognitive impairment and dementia
Pericytes are unique, multi-functional mural cells localized at the abluminal side of the
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …
A human three-dimensional neural-perivascular 'assembloid'promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology
Clinical evidence suggests the central nervous system is frequently impacted by SARS-CoV-
2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are …
2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are …
Human iPSC-derived blood-brain barrier chips enable disease modeling and personalized medicine applications
The blood-brain barrier (BBB) tightly regulates the entry of solutes from blood into the brain
and is disrupted in several neurological diseases. Using Organ-Chip technology, we created …
and is disrupted in several neurological diseases. Using Organ-Chip technology, we created …
Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes
In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition
known as cerebral amyloid angiopathy (CAA), which impairs blood–brain barrier (BBB) …
known as cerebral amyloid angiopathy (CAA), which impairs blood–brain barrier (BBB) …
Transcriptomic comparison of human and mouse brain microvessels
HW Song, KL Foreman, BD Gastfriend, JS Kuo… - Scientific reports, 2020 - nature.com
The brain vasculature maintains brain homeostasis by tightly regulating ionic, molecular,
and cellular transport between the blood and the brain parenchyma. These blood–brain …
and cellular transport between the blood and the brain parenchyma. These blood–brain …
[HTML][HTML] An overview of in vitro 3D models of the blood-brain barrier as a tool to predict the in vivo permeability of nanomedicines
A Pérez-López, AI Torres-Suárez… - Advanced Drug Delivery …, 2023 - Elsevier
The blood–brain barrier (BBB) prevents efficient drug delivery to the central nervous system.
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …
Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice
J Sun, Y Huang, J Gong, J Wang, Y Fan, J Cai… - Nature …, 2020 - nature.com
Pericytes play essential roles in blood–brain barrier (BBB) integrity and dysfunction or
degeneration of pericytes is implicated in a set of neurological disorders although the …
degeneration of pericytes is implicated in a set of neurological disorders although the …
Emulating human tissues and organs: a bioprinting perspective toward personalized medicine
The lack of in vitro tissue and organ models capable of mimicking human physiology
severely hinders the development and clinical translation of therapies and drugs with higher …
severely hinders the development and clinical translation of therapies and drugs with higher …
Commentary on human pluripotent stem cell-based blood–brain barrier models
In 2012, we provided the first published evidence that human pluripotent stem cells could be
differentiated to cells exhibiting markers and phenotypes characteristic of the blood–brain …
differentiated to cells exhibiting markers and phenotypes characteristic of the blood–brain …