Rho GTPases are molecular switches that regulate many essential cellular processes,
including actin dynamics, gene transcription, cell-cycle progression and cell adhesion …

Cdc42p is an essential GTPase that belongs to the Rho/Rac subfamily of Ras-like GTPases.
These proteins act as molecular switches by responding to exogenous and/or endogenous …

The IQGAP family comprises three proteins in humans. The best characterized is IQGAP1,
which participates in protein–protein interactions and integrates diverse signaling pathways …

The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad
intracellular distribution and is present in numerous compartments, including the plasma …

The dynamic rearrangement of cell-cell adhesion is one of the major physiological events in
tissue development and tumor metastasis. Polarized cell migration, another key event, is a …

IQGAP proteins have been identified in a wide spectrum of organisms, ranging from yeast to
humans. The most extensively studied family member is the ubiquitously expressed scaffold …

Typical members of the Ras superfamily of small monomeric GTP-binding proteins function
as regulators of diverse processes by cycling between biologically active GTP-and inactive …

IQGAP1 is a scaffolding protein that binds to a diverse array of signalling and structural
molecules. By interacting with its target proteins, human IQGAP1 participates in multiple …

IQGAP1 was identified in 1994 as a widely expressed IQ domain-containing protein with a
region containing sequence similarity to the Ras GTPase-activating proteins. IQGAP1 has …

Since its discovery in 1994, recognized cellular functions for the scaffold protein IQGAP1
have expanded immensely. Over 100 unique IQGAP1-interacting proteins have been …