To better understand the reward circuitry in human brain, we conducted activation likelihood
estimation (ALE) and parametric voxel-based meta-analyses (PVM) on 142 neuroimaging …

Prediction errors (PE) are a central notion in theoretical models of reinforcement learning,
perceptual inference, decision-making and cognition, and prediction error signals have …

Humans and animals prefer immediate over delayed rewards (delay discounting). This
preference for smaller-but-sooner over larger-but-later rewards shows substantial …

A fundamental function of the brain is to evaluate the emotional and motivational
significance of stimuli and to adapt behaviour accordingly. The IMAGEN study is the first …

Given the high prevalence and burden of mental disorders, fostering the understanding of
protective factors is an urgent issue for translational medicine in psychiatry. The concept of …

Nonspecific histone deacetylase (HDAC) inhibition has been shown to facilitate the
extinction of drug-seeking behavior in a manner resistant to reinstatement. A key open …

Addictions are often characterized as forms of impulsive behavior. That said, it is often noted
that impulsivity is a multidimensional construct, spanning several psychological domains …

To make sound economic decisions, the brain needs to compute several different value-
related signals. These include goal values that measure the predicted reward that results …

Sexual behavior is critical to species survival, yet comparatively little is known about the
neural mechanisms in the human brain. Here we systematically review the existing human …

Over the past 20 years there has been an increasing number of brain imaging studies on the
mechanisms underlying reward motivation in humans. This narrative review describes …