During the past decade, proof of the principle that peptide receptors can be used
successfully for in vivo targeting of human cancers has been provided. The molecular basis …

Neuroblastoma stands out among pediatric solid tumors because of its relative frequency,
intriguing natural history, prognostic biologic features, and therapeutic challenges. It is the …

Nuclear medicine has a central role in the diagnosis, staging, response assessment and
long-term follow-up of neuroblastoma, the most common solid extracranial tumour in …

This study tested the principle that 68Ga-DOTATATE PET/CT may be used to select children
with primary refractory or relapsed high-risk neuroblastoma for treatment with 177Lu …

Materials and Methods: GaTATE studies (8 patients; 2 to 9 years old) were reviewed and
compared with 123 I-MIBG or posttreatment 131 I-MIBG studies. Immunohistochemistry …

Neuroblastoma is the most common extracranial solid malignancy in children. At diagnosis,
approximately 50% of patients present with metastatic disease. These patients are at high …

While recent increases in our understanding of the biology of neuroblastoma have allowed
for more precise risk stratification and improved outcomes for many patients, children with …

Somatostatin, a naturally occurring 14-amino acid peptide, can be thought of as an anti-
growth hormone and functional down-regulator of sensitive tissue. Most neuroendocrine …

We hypothesized that non-proliferating (quiescent) human vascular endothelial cells would
not express somatostatin receptor subtype 2 (sst 2) and that this receptor would be …

Neuroblastoma is an embryonic tumor of the peripheral sympathetic nervous system and is
metastatic or high risk for relapse in nearly 50% of cases. Therefore, exact staging with …