Acoustofluidic separation of cells and particles

M Wu, A Ozcelik, J Rufo, Z Wang, R Fang… - Microsystems & …, 2019 - nature.com
Acoustofluidics, the integration of acoustics and microfluidics, is a rapidly growing research
field that is addressing challenges in biology, medicine, chemistry, engineering, and …

Circulating tumor cell isolation, culture, and downstream molecular analysis

S Sharma, R Zhuang, M Long, M Pavlovic, Y Kang… - Biotechnology …, 2018 - Elsevier
Circulating tumor cells (CTCs) are a major contributor of cancer metastases and hold a
promising prognostic significance in cancer detection. Performing functional and molecular …

Iso-acoustic focusing of cells for size-insensitive acousto-mechanical phenotyping

P Augustsson, JT Karlsen, HW Su, H Bruus… - Nature …, 2016 - nature.com
Mechanical phenotyping of single cells is an emerging tool for cell classification, enabling
assessment of effective parameters relating to cells' interior molecular content and structure …

Microfluidic droplet handling by bulk acoustic wave (BAW) acoustophoresis

I Leibacher, P Reichert, J Dual - Lab on a Chip, 2015 - pubs.rsc.org
Droplet microfluidics has emerged as a prospering field for lab-on-a-chip devices, where
droplets serve as liquid vessels eg for biochemical reagents. Key to the fluid processing in …

Acoustofluidic, label-free separation and simultaneous concentration of rare tumor cells from white blood cells

M Antfolk, C Magnusson, P Augustsson, H Lilja… - Analytical …, 2015 - ACS Publications
Enrichment of rare cells from peripheral blood has emerged as a means to enable
noninvasive diagnostics and development of personalized drugs, commonly associated with …

High-throughput acoustic separation of platelets from whole blood

Y Chen, M Wu, L Ren, J Liu, PH Whitley, L Wang… - Lab on a Chip, 2016 - pubs.rsc.org
Platelets contain growth factors which are important in biomedical and clinical applications.
In this work, we present an acoustic separation device for high-throughput, non-invasive …

Acoustic impedance matched buffers enable separation of bacteria from blood cells at high cell concentrations

P Ohlsson, K Petersson, P Augustsson, T Laurell - Scientific reports, 2018 - nature.com
Sepsis is a common and often deadly systemic response to an infection, usually caused by
bacteria. The gold standard for finding the causing pathogen in a blood sample is blood …

Acoustic separation in plastic microfluidics for rapid detection of bacteria in blood using engineered bacteriophage

P Dow, K Kotz, S Gruszka, J Holder, J Fiering - Lab on a Chip, 2018 - pubs.rsc.org
A more effective treatment of bacteremia requires a diagnostic platform that is both sensitive,
accurate and rapid. Currently, clinical laboratory techniques require growth of bacteria prior …

A single inlet two-stage acoustophoresis chip enabling tumor cell enrichment from white blood cells

M Antfolk, C Antfolk, H Lilja, T Laurell, P Augustsson - Lab on a chip, 2015 - pubs.rsc.org
Metastatic disease is responsible for most cancer deaths, and hematogenous spread
through circulating tumor cells (CTC) is a prerequisite for tumor dissemination. CTCs may …

Acoustic force density acting on inhomogeneous fluids in acoustic fields

JT Karlsen, P Augustsson, H Bruus - Physical review letters, 2016 - APS
We present a theory for the acoustic force density acting on inhomogeneous fluids in
acoustic fields on time scales that are slow compared to the acoustic oscillation period. The …