Pharmacokinetics and pharmacodynamics of cyclodextrin-based oral drug delivery formulations for disease therapy

H Liu, S Guo, S Wei, J Liu, B Tian - Carbohydrate Polymers, 2024 - Elsevier
Oral drug administration has become the most common and preferred mode of disease
treatment due to its good medication adherence and convenience. For orally administered …

Chitosan-based intelligent polymeric networks for site-specific colon medication delivery: A comprehensive study on controlled release of diloxanide furoate and …

A Mahmood, A Mahmood, RM Sarfraz… - International Journal of …, 2024 - Elsevier
Oral medications are prone to gastric degradation and enzymatic inactivation, diminishing
their efficacy. This study investigates a solution by developing intelligent polymeric networks …

Bioapplication of cyclodextrin-containing montmorillonite

S Cao, C Liu, L Zhou, H Zhang, Y Zhao… - Journal of Materials …, 2021 - pubs.rsc.org
Recent progresses in the integration of CDs and montmorillonite, as well as applications of
CD-containing montmorillonite hybrid host systems are summarized in this review. Several …

Hydroxypropyl methylcellulose-based hydrogel copolymeric for controlled delivery of galantamine hydrobromide in Dementia

S Bashir, N Zafar, N Lebaz, A Mahmood, A Elaissari - Processes, 2020 - mdpi.com
The study aims to prepare a smart copolymeric for controlled delivery of Galantamine
hydrobromide. The synthesis of the hydrogel was executed through free radical …

Oral administration of pH-responsive polyamine modified cyclodextrin nanoparticles for controlled release of anti-tumor drugs

BL Li, J Zhang, W Jin, XY Chen, JM Yang… - Reactive and Functional …, 2022 - Elsevier
Abstract pH-responsive nanoparticles based on polyamine modified β-cyclodextrin (PEHA-β-
CD) and sodium dodecylbenzene sulfonate (SDBS) were fabricated through electrostatic …

Tamarind/β-CD-g-poly (MAA) pH responsive hydrogels for controlled delivery of Capecitabine: fabrication, characterization, toxicological and pharmacokinetic …

U Rehman, RM Sarfraz, A Mahmood… - Journal of Polymer …, 2023 - Springer
The present study was aimed for controlled delivery of capecitabine, an anticancer drug
used to treat colorectal cancer. Smart pH responsive tamarind/-CD-g-poly (MAA) hydrogels …

Novel black seed polysaccharide extract-g-poly (acrylate) pH-responsive hydrogel nanocomposites for safe oral insulin delivery: development, in vitro, in vivo and …

F Shabir, A Mahmood, N Zafar, M Zaman, RM Sarfraz… - Pharmaceutics, 2022 - mdpi.com
Oral delivery of insulin has always been a challenging task due to harsh gut environment
involving variable pH and peptidase actions. Currently, no Food and Drug Administration …

Development of tofacitinib loaded pH-responsive chitosan/mucin based hydrogel microparticles: in-vitro characterization and toxicological screening

RT Malatani, S Bilal, A Mahmood, RM Sarfraz, N Zafar… - Gels, 2023 - mdpi.com
Tofacitinib is an antirheumatic drug characterized by a short half-life and poor permeability,
which necessitates the development of sustained release formulation with enhanced …

Fenugreek seed mucilage grafted poly methacrylate pH-responsive hydrogel: A promising tool to enhance the oral bioavailability of methotrexate

HR Hussain, S Bashir, A Mahmood, RM Sarfraz… - International Journal of …, 2022 - Elsevier
This study aimed to develop the Fenugreek seed mucilage-based pH-responsive hydrogel
system in order to improve the oral bioavailability of methotrexate (MTX). Fenugreek seed …

Hydrogel-based intelligent delivery system for controlled release of diloxanide furoate

A Mahmood, A Mahmood, RM Sarfraz, H Ijaz, N Zafar… - Polymer Bulletin, 2023 - Springer
In current research work, pH responsive pectin-co-poly (MAA) hydrogels containing
diloxanide furoate were developed by graft polymerization of pectin and methacrylic acid, for …