Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes mellitus: cardiovascular and kidney effects, potential mechanisms, and clinical applications

HJL Heerspink, BA Perkins, DH Fitchett, M Husain… - Circulation, 2016 - Am Heart Assoc
Sodium-glucose cotransporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin,
and canagliflozin, are now widely approved antihyperglycemic therapies. Because of their …

[HTML][HTML] Renoprotective effects of sodium-glucose cotransporter-2 inhibitors

HJL Heerspink, M Kosiborod, SE Inzucchi… - Kidney international, 2018 - Elsevier
Over the past two years, our understanding of anti-hyperglycemic medications used to treat
patients with type 2 diabetes (T2D) has fundamentally changed. Before the EMPA-REG …

The intersection between food insecurity and diabetes: a review

E Gucciardi, M Vahabi, N Norris, JP Del Monte… - Current nutrition …, 2014 - Springer
Access to sufficient, safe, and nutritious food not only affects the health of people who
experience food insecurity, but also their ability to manage health conditions, such as …

Mortality risk among sulfonylureas: a systematic review and network meta-analysis

SH Simpson, J Lee, S Choi, B Vandermeer… - The lancet Diabetes & …, 2015 - thelancet.com
Background Sulfonylureas are common second-line options for management of type 2
diabetes; however, they are associated with a higher risk of cardiovascular events compared …

Rationale and design of the glycemia reduction approaches in diabetes: a comparative effectiveness study (GRADE)

DM Nathan, JB Buse, SE Kahn… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE The epidemic of type 2 diabetes (T2DM) threatens to become the major public
health problem of this century. However, a comprehensive comparison of the long-term …

Empagliflozin: a review in type 2 diabetes

JE Frampton - Drugs, 2018 - Springer
Empagliflozin (Jardiance®), a potent, highly selective, sodium glucose cotransporter-2
(SGLT2) inhibitor, is an effective and generally well tolerated antihyperglycaemic agent …

Perirenal adipose tissue inflammation: novel insights linking metabolic dysfunction to renal diseases

SH Hammoud, I AlZaim, Y Al-Dhaheri, AH Eid… - Frontiers in …, 2021 - frontiersin.org
A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it
contributes to energy homeostasis and provides insulation for internal organs. Adipocytes …

Dapagliflozin improves glycemic control and reduces body weight as add-on therapy to metformin plus sulfonylurea: a 24-week randomized, double-blind clinical trial

S Matthaei, K Bowering, K Rohwedder, A Grohl… - Diabetes …, 2015 - Am Diabetes Assoc
OBJECTIVE To evaluate the efficacy and safety of dapagliflozin in patients with type 2
diabetes inadequately controlled with metformin and sulfonylurea. RESEARCH DESIGN …

Can pulses play a role in improving cardiometabolic health? Evidence from systematic reviews and metaanalyses

E Viguiliouk, S Blanco Mejia… - Annals of the New …, 2017 - Wiley Online Library
Obesity, diabetes, and cardiovascular disease (CVD) present important unmet prevention
and treatment challenges. Dietary pulses are sustainable, affordable, and nutrientdense …

Prescription medication use by Canadians aged 6 to 79

M Rotermann, C Sanmartin, D Hennessy… - Health …, 2014 - search.proquest.com
Based on data from the 2007 to 2009 and 2009 to 2011 Canadian Health Measures Survey,
this article provides national information about prescription medication use among …