The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents
Rats and mice are attracted by novel objects. They readily approach novel objects and
explore them with their vibrissae, nose and forepaws. It is assumed that such a single …
explore them with their vibrissae, nose and forepaws. It is assumed that such a single …
Involvement of nitric oxide in learning & memory processes
V Paul, P Ekambaram - Indian journal of medical research, 2011 - journals.lww.com
Nitric oxide (NO), synthesized from the amino acid, L-arginine by nitric oxide synthase (NOS)
has received attention as a neurotransmitter in the brain. NO has been found to induce …
has received attention as a neurotransmitter in the brain. NO has been found to induce …
Pattern separation deficits may contribute to age-associated recognition impairments.
SN Burke, JL Wallace, S Nematollahi… - Behavioral …, 2010 - psycnet.apa.org
Normal aging is associated with impairments in stimulus recognition. In the current
investigation, object recognition was tested in adult and aged rats with the standard …
investigation, object recognition was tested in adult and aged rats with the standard …
The role of free radicals in cerebral hypoxia and ischemia
J Rodrigo, AP Fernandez, J Serrano… - Free Radical Biology …, 2005 - Elsevier
This review focuses on the effects that ischemia and hypoxia have on the cerebral cortex
and the cerebellum during different periods of life. The acute interruption or reduction of …
and the cerebellum during different periods of life. The acute interruption or reduction of …
Cardiovascular disease, the nitric oxide pathway and risk of cognitive impairment and dementia
Abstract Purpose of Review In this review, we summarise the evidence on the association
between cardiovascular disease (CVD) and cognitive impairment and explore the role of the …
between cardiovascular disease (CVD) and cognitive impairment and explore the role of the …
Age-specific effects of voluntary exercise on memory and the older brain
BACKGROUND: Physical exercise in early adulthood and mid-life improves cognitive
function and enhances brain plasticity, but the effects of commencing exercise in late …
function and enhances brain plasticity, but the effects of commencing exercise in late …
[HTML][HTML] Deficiency of endothelial nitric oxide synthase (eNOS) exacerbates brain damage and cognitive deficit in a mouse model of vascular dementia
Abstract Vascular Dementia (VaD) accounts for nearly 20% of all cases of dementia. eNOS
plays an important role in neurovascular remodeling, anti-inflammation, and cognitive …
plays an important role in neurovascular remodeling, anti-inflammation, and cognitive …
Age‐related impairment in a complex object discrimination task that engages perirhinal cortex
L Ryan, JA Cardoza, MD Barense, KH Kawa… - …, 2012 - Wiley Online Library
Previous lesion studies have shown compromised complex object discrimination in rats,
monkeys, and human patients with damage to the perirhinal cortical region (PRC) of the …
monkeys, and human patients with damage to the perirhinal cortical region (PRC) of the …
Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery
The development of small molecule modulators of NO/cGMP signaling for use in the CNS
has lagged far behind the use of such clinical agents in the periphery, despite the central …
has lagged far behind the use of such clinical agents in the periphery, despite the central …
Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats
AV Terry Jr, A Kutiyanawalla, A Pillai - Physiology & behavior, 2011 - Elsevier
The objective of this study was to evaluate the effects of aging on the performance of specific
memory-related tasks in rats as well as to determine the levels of several nerve growth factor …
memory-related tasks in rats as well as to determine the levels of several nerve growth factor …