Mitigating off‐target effects of small RNAs: conventional approaches, network theory and artificial intelligence

Z Bereczki, B Benczik, OM Balogh… - British Journal of …, 2025 - Wiley Online Library
Three types of highly promising small RNA therapeutics, namely, small interfering RNAs
(siRNAs), microRNAs (miRNAs) and the RNA subtype of antisense oligonucleotides (ASOs) …

Natural product pharmacology: the British Journal of Pharmacology perspective

X Wang, AA Izzo, A Papapetropoulos… - British Journal of …, 2024 - Wiley Online Library
Natural products (NPs) have long been used as a rich source of bioactive compounds for
drug development. Recent technological advancements have revitalised natural products …

miR‐210 as a therapeutic target in diabetes‐associated endothelial dysfunction

A Collado, T Jiao, E Kontidou… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose MicroRNA (miR)‐210 function in endothelial cells and its
role in diabetes‐associated endothelial dysfunction are not fully understood. We aimed to …

The PARP inhibitor rucaparib blocks SARS‐CoV‐2 virus binding to cells and the immune reaction in models of COVID‐19

H Papp, E Tóth, J Bóvári‐Biri, K Bánfai… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose To date, there are limited options for severe Coronavirus
disease 2019 (COVID‐19), caused by SARS‐CoV‐2 virus. As ADP‐ribosylation events are …

Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by amyloid‐β (Aβ) oligomers

LP Diniz, J Morgado… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Inhibitors of histone deacetylases (iHDACs) are promising drugs
for neurodegenerative diseases. We have evaluated the therapeutic potential of the new …

Anti‐chitinase‐3‐like 1 antibody attenuated atopic dermatitis‐like skin inflammation through inhibition of STAT3‐dependent CXCL8 expression

JE Yu, SH Jeon, MJ Kim, DH Kim… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Chitinase‐3‐like 1 (CHI3L1) causes skin inflammation in
the progression of atopic dermatitis. We investigated if anti‐CHI3L1 antibody could prevent …

Inhibition of dynamin‐related protein 1‐filamin interaction improves systemic glucose metabolism

Y Kato, K Ariyoshi, Y Nohara… - British Journal of …, 2024 - Wiley Online Library
Background and purpose Maintaining mitochondrial quality is attracting attention as a new
strategy to treat diabetes and diabetic complications. We previously reported that …

A high‐precision view of intercompartmental drug transport via simultaneous, seconds‐resolved, in situ measurements in the vein and brain

J Gerson, MK Erdal… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose The ability to measure specific molecules at multiple sites within
the body simultaneously, and with a time resolution of seconds, could greatly advance our …

Therapeutic and pharmacological applications of extracellular vesicles and lipoproteins

K Németh, BM Kestecher, S Ghosal… - British Journal of …, 2024 - Wiley Online Library
In recent years, various approaches have been undertaken to eliminate lipoproteins co‐
isolated with extracellular vesicles, as they were initially regarded as contaminating entities …

Glycyrrhetinic acid blocks SARS‐CoV‐2 infection by activating the cGAS‐STING signalling pathway

H Qi, Q Ma, W Feng, S Chen, C Wu… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Traditional Chinese medicine (TCM) played an important role in
controlling the COVID‐19 pandemic, but the scientific basis and its active ingredients are still …