Mitigating off‐target effects of small RNAs: conventional approaches, network theory and artificial intelligence
Three types of highly promising small RNA therapeutics, namely, small interfering RNAs
(siRNAs), microRNAs (miRNAs) and the RNA subtype of antisense oligonucleotides (ASOs) …
(siRNAs), microRNAs (miRNAs) and the RNA subtype of antisense oligonucleotides (ASOs) …
Natural product pharmacology: the British Journal of Pharmacology perspective
X Wang, AA Izzo, A Papapetropoulos… - British Journal of …, 2024 - Wiley Online Library
Natural products (NPs) have long been used as a rich source of bioactive compounds for
drug development. Recent technological advancements have revitalised natural products …
drug development. Recent technological advancements have revitalised natural products …
miR‐210 as a therapeutic target in diabetes‐associated endothelial dysfunction
Abstract Background and Purpose MicroRNA (miR)‐210 function in endothelial cells and its
role in diabetes‐associated endothelial dysfunction are not fully understood. We aimed to …
role in diabetes‐associated endothelial dysfunction are not fully understood. We aimed to …
The PARP inhibitor rucaparib blocks SARS‐CoV‐2 virus binding to cells and the immune reaction in models of COVID‐19
Abstract Background and Purpose To date, there are limited options for severe Coronavirus
disease 2019 (COVID‐19), caused by SARS‐CoV‐2 virus. As ADP‐ribosylation events are …
disease 2019 (COVID‐19), caused by SARS‐CoV‐2 virus. As ADP‐ribosylation events are …
Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by amyloid‐β (Aβ) oligomers
LP Diniz, J Morgado… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Inhibitors of histone deacetylases (iHDACs) are promising drugs
for neurodegenerative diseases. We have evaluated the therapeutic potential of the new …
for neurodegenerative diseases. We have evaluated the therapeutic potential of the new …
Anti‐chitinase‐3‐like 1 antibody attenuated atopic dermatitis‐like skin inflammation through inhibition of STAT3‐dependent CXCL8 expression
Abstract Background and Purpose Chitinase‐3‐like 1 (CHI3L1) causes skin inflammation in
the progression of atopic dermatitis. We investigated if anti‐CHI3L1 antibody could prevent …
the progression of atopic dermatitis. We investigated if anti‐CHI3L1 antibody could prevent …
Inhibition of dynamin‐related protein 1‐filamin interaction improves systemic glucose metabolism
Y Kato, K Ariyoshi, Y Nohara… - British Journal of …, 2024 - Wiley Online Library
Background and purpose Maintaining mitochondrial quality is attracting attention as a new
strategy to treat diabetes and diabetic complications. We previously reported that …
strategy to treat diabetes and diabetic complications. We previously reported that …
A high‐precision view of intercompartmental drug transport via simultaneous, seconds‐resolved, in situ measurements in the vein and brain
J Gerson, MK Erdal… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose The ability to measure specific molecules at multiple sites within
the body simultaneously, and with a time resolution of seconds, could greatly advance our …
the body simultaneously, and with a time resolution of seconds, could greatly advance our …
Therapeutic and pharmacological applications of extracellular vesicles and lipoproteins
K Németh, BM Kestecher, S Ghosal… - British Journal of …, 2024 - Wiley Online Library
In recent years, various approaches have been undertaken to eliminate lipoproteins co‐
isolated with extracellular vesicles, as they were initially regarded as contaminating entities …
isolated with extracellular vesicles, as they were initially regarded as contaminating entities …
Glycyrrhetinic acid blocks SARS‐CoV‐2 infection by activating the cGAS‐STING signalling pathway
H Qi, Q Ma, W Feng, S Chen, C Wu… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Traditional Chinese medicine (TCM) played an important role in
controlling the COVID‐19 pandemic, but the scientific basis and its active ingredients are still …
controlling the COVID‐19 pandemic, but the scientific basis and its active ingredients are still …