Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), also referred to as
BCR-ABL1–like ALL, is a high-risk subset with a gene expression profile that shares …

In 2018, 550,000 people were diagnosed with bladder cancer (BC), of which nearly 200,000
people died. Moreover, men are 4 times more likely than women to be diagnosed with BC …

Mislocated enzymatic activity of DOT1L has been proposed as a driver of leukemogenesis in
mixed lineage leukemia (MLL). The characterization of EPZ004777, a potent, selective …

Fusion genes are potent driver mutations in cancer. In this study, we delineate the fusion
gene landscape in a consecutive series of 195 paediatric B-cell precursor acute …

Recurrent chromosomal rearrangements have not been well characterized in common
carcinomas. We used a bioinformatics approach to discover candidate oncogenic …

Background Genetic subtypes of acute lymphoblastic leukaemia (ALL) are used to
determine risk and treatment in children. 25% of precursor B-ALL cases are genetically …

Purpose The Microarray Innovations in Leukemia study assessed the clinical utility of gene
expression profiling as a single test to subtype leukemias into conventional categories of …

Chromosomal aberrations are a hallmark of acute lymphoblastic leukaemia (ALL) but alone
fail to induce leukaemia. To identify cooperating oncogenic lesions, we performed a genome …

Background Although aberrant DNA methylation has been observed previously in acute
lymphoblastic leukemia (ALL), the patterns of differential methylation have not been …

Gene expression profiling of 207 uniformly treated children with high-risk B-progenitor acute
lymphoblastic leukemia revealed 29 of 207 cases (14%) with markedly elevated expression …