Immune checkpoint inhibitors in cancer therapy
The discovery of immune checkpoint proteins such as PD-1/PDL-1 and CTLA-4 represents a
significant breakthrough in the field of cancer immunotherapy. Therefore, humanized …
significant breakthrough in the field of cancer immunotherapy. Therefore, humanized …
Combination therapy with immune checkpoint inhibitors (ICIs); a new frontier
Recently, immune checkpoint inhibitors (ICIs) therapy has become a promising therapeutic
strategy with encouraging therapeutic outcomes due to their durable anti-tumor effects …
strategy with encouraging therapeutic outcomes due to their durable anti-tumor effects …
Nanoparticle‐mediated radiotherapy remodels the tumor microenvironment to enhance antitumor efficacy
Radiotherapy (RT) uses ionizing radiation to eradicate localized tumors and, in rare cases,
control tumors outside of the irradiated fields via stimulating an antitumor immune response …
control tumors outside of the irradiated fields via stimulating an antitumor immune response …
Small‐molecule prodrug nanoassemblies: an emerging nanoplatform for anticancer drug delivery
G Li, B Sun, Y Li, C Luo, Z He, J Sun - Small, 2021 - Wiley Online Library
The antitumor efficiency and clinical translation of traditional nanomedicines is mainly
restricted by low drug loading, complex preparation technology, and potential toxicity …
restricted by low drug loading, complex preparation technology, and potential toxicity …
Tumor microenvironment as a “game changer” in cancer radiotherapy
M Jarosz-Biej, R Smolarczyk, T Cichoń… - International journal of …, 2019 - mdpi.com
Radiotherapy (RT), besides cancer cells, also affects the tumor microenvironment (TME):
tumor blood vessels and cells of the immune system. It damages endothelial cells and …
tumor blood vessels and cells of the immune system. It damages endothelial cells and …
Recent advances in nanomaterial-based synergistic combination cancer immunotherapy
In recent years, conventional treatments including surgery, chemotherapy and radiotherapy
have been the main approaches in tumour therapy. Cancer immunotherapy is a new …
have been the main approaches in tumour therapy. Cancer immunotherapy is a new …
Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H2O2 and Catalase for Enhanced Radio-Immunotherapy of Cancer
The recent years have witnessed the blooming of cancer immunotherapy, as well as their
combinational use together with other existing cancer treatment techniques including …
combinational use together with other existing cancer treatment techniques including …
PD-1 and PD-L1 antibodies in cancer: current status and future directions
AV Balar, JS Weber - Cancer Immunology, Immunotherapy, 2017 - Springer
Immunotherapy has moved to the center stage of cancer treatment with the recent success of
trials in solid tumors with PD-1/PD-L1 axis blockade. Programmed death-1 or PD-1 is a …
trials in solid tumors with PD-1/PD-L1 axis blockade. Programmed death-1 or PD-1 is a …
The pro-tumorigenic host response to cancer therapies
Y Shaked - Nature Reviews Cancer, 2019 - nature.com
Resistance to cancer therapy remains a major challenge in clinical oncology. Although the
initial treatment phase is often successful, eventual resistance, characterized by tumour …
initial treatment phase is often successful, eventual resistance, characterized by tumour …
Diselenide–Pemetrexed assemblies for combined cancer Immuno‐, radio‐, and chemotherapies
T Li, S Pan, S Gao, W Xiang, C Sun… - Angewandte Chemie …, 2020 - Wiley Online Library
Immunotherapy has emerged as a promising new approach for cancer treatment. However,
clinically available drugs have been limited until recently, and the antitumor efficacy of most …
clinically available drugs have been limited until recently, and the antitumor efficacy of most …