Meiotic recombination is one of the most important driving forces of biological evolution,
which is initiated by double-strand DNA breaks. Recombination has important roles in …

Drug resistance in cancer cells significantly diminishes treatment efficacy, leading to
recurrence and metastasis. A critical factor contributing to this resistance is the epigenetic …

Antimicrobial peptides (AMPs) are a valuable source of antimicrobial agents and a potential
solution to the multi-drug resistance problem. In particular, short-length AMPs have been …

Motivation RNA modifications play critical roles in a series of cellular and developmental
processes. Knowledge about the distributions of RNA modifications in the transcriptomes …

Background: Thermophilic proteins can maintain good activity under high temperature,
therefore, it is important to study thermophilic proteins for the thermal stability of proteins …

Messenger RNAs (mRNAs) shoulder special responsibilities that transmit genetic code from
DNA to discrete locations in the cytoplasm. The locating process of mRNA might provide …

Thermophilic proteins have various practical applications in theoretical research and in
industry. In recent years, the demand for thermophilic proteins on an industrial scale has …

AlkB homologs (ALKBH) are a family of specific demethylases that depend on Fe 2+ and α-
ketoglutarate to catalyze demethylation on different substrates, including ssDNA, dsDNA …

Abstract N4-methylcytosine (4mC) is a type of DNA modification which could regulate
several biological progressions such as transcription regulation, replication and gene …

DNA N6-methyladenine (6mA) is a dominant DNA modification form and involved in many
biological functions. The accurate genome-wide identification of 6mA sites may increase …