Acute myeloid leukemia (AML) is a devastating disease, with the majority of patients dying
within a year of diagnosis. For patients with relapsed/refractory AML, the prognosis is …

Acute myeloid leukemia is mainly characterized by a complex and dynamic genomic
instability. Next-generation sequencing has significantly improved the ability of diagnostic …

Neoantigens derived from non-synonymous somatic mutations are restricted to malignant
cells and are thus considered ideal targets for T cell receptor (TCR)-based immunotherapy …

Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L‑type; R‑type; N‑
type; P/Q‑type; and T‑type, which are encoded by α1 subunit genes. Calcium ion channels …

Circular RNAs (circRNAs) are a novel class of powerful regulators in gene expression and
participate in the pathogenesis of many diseases, including cancer. However, little is known …

Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, and generally
considered to be caused by environment and genetic factors. In this study, we combined a …

Extensive studies on tumor suppressor genes (TSGs) are helpful to understand the
pathogenesis of cancer and design effective treatments. However, identifying TSGs using …

Simple Summary Acute myeloid leukemia (AML) is a cancer of blood and bone marrow that
causes rapid production of abnormal red and white blood cells. Once established, the …

Background The increasing genomic complexity of acute myeloid leukemia (AML), the most
common form of acute leukemia, poses a major challenge to its therapy. To identify potent …

Abstract Background Acute Myeloid Leukemia (AML) is a malignancy of myeloid precursor
cells that arise from genomic alterations in the expression of key growth regulatory genes …