Summary 2′, 3′-cAMP is a positional isomer of the well-established second messenger
3′, 5′-cAMP, but little is known about the biology of this noncanonical cyclic nucleotide …

Intratumoral hypoxia and hypoxia inducible factor-1α (HIF-1-α)-dependent CD39/CD73
ectoenzymes may govern the accumulation of tumor-protecting extracellular adenosine and …

Our recent studies employing HPLC-tandem mass spectrometry to analyze venous
perfusate from isolated, perfused kidneys demonstrate that intact kidneys produce and …

Cyclic-3′, 5′-adenosine monophosphate (cAMP) is a universal second messenger that
regulates vital activities in bacteria and eukaryotes. Enzymes that hydrolyze cAMP, called …

We examined the analysis of nucleotides and nucleotide sugars by chromatography on
porous graphitic carbon with mass spectrometric detection, a method that evades …

Abstract 2′, 3′-cAMP is an intriguing small molecule that is conserved among different
kingdoms. 2′, 3′-cAMP is presumably produced during RNA degradation, with increased …

The role of the RNA degradation product 2′, 3′-cyclic adenosine monophosphate (2′,
3′-cAMP) is poorly understood. Recent studies have identified 2′, 3′-cAMP in plant …

Research on nucleotide-based second messengers began in 1956 with the discovery of
cyclic adenosine monophosphate (3′, 5′-cAMP) by Earl Wilbur Sutherland and his co …

We discovered that renal injury releases 2′, 3′-cAMP (positional isomer of 3′, 5′-
cAMP) into the interstitium. This finding motivated a novel hypothesis: renal injury leads to …

Urate has emerged as a promising target for neuroprotection based on epidemiological
observations, preclinical models, and early clinical trial results in multiple neurologic …