Sperm DNA integrity is essential for the accurate transmission of genetic information. It has a
highly compact and complex structure and is capable of decondensation—features that must …

Immune privilege is a property of some sites in the body, whereby immune responses are
limited or prevented. One explanation that has been proposed for this phenomenon is …

The function of the blood–testis barrier is to protect germ cells from harmful influences; thus,
it also impedes the delivery of chemotherapeutic drugs to the testis. The barrier has three …

Dysregulation of male germ cell apoptosis has been associated with the pathogenesis of
male infertility. Therefore, factors involved in the regulation of germ cell death are being …

The testis is an immunological privileged tissue as evidenced by its ability to support grafts
with minimal rejection. Immune privilege is essential for the tolerance of neo-antigens from …

Spermatogenesis is contingent upon hormones and growth factors acting through endocrine
and paracrine pathways either in vivo or in vitro. Sertoli cells (SCs) furnish essential factors …

The testis is the main source of Fas ligand (FasL) mRNA in rodents; it is generally believed
that this molecule, expressed on bordering somatic Sertoli cells, bestows an immune …

In this study we extended earlier work to determine whether sperm respond to somatic cell
apoptotic stimuli and whether apoptotic phenotypes are significant indicators of human …

It has long been known that the testis is an immunologically privileged site in the body, and
that human seminal plasma possesses a generalized immunosuppressive activity. Multiple …

BACKGROUND: Caspases are downstream elements of apoptosis-mediating pathways
initiated by the Fas ligand/Fas receptor system which is supposed to play a central role in …